Rezk Rogina, Hanna Abanob George, Hutchinson Hunter, Farag Mariam, Lucke-Wold Brandon
College of Medicine, University of Florida, Gainesville, FL 32610, USA.
Department of Neurosurgery, University of Florida, Gainesville, FL 32608, USA.
Biomedicines. 2025 Jun 12;13(6):1452. doi: 10.3390/biomedicines13061452.
Primary brain tumors represent a significant focus of contemporary research. With advancements in technology and the increasing detection of cases through novel diagnostic methods, innovative therapies and approaches to chemotherapy continue to emerge. The paper explores recent advancements in chemotherapy for glioblastoma, highlighting innovative approaches that provide valuable mechanistic insights. It delves into the mechanisms of action, molecular targets, and the future potential of emerging therapies for gliomas. Additionally, this paper offers an overview investigating a range of therapies, including various chemotherapeutic agents, CAR-T cell therapies, drugs targeting cellular respiration, and other approaches. Furthermore, the paper addresses chemotherapy-related challenges, including the blood-brain barrier, drug resistance, and immunosuppression, while proposing potential solutions to overcome these obstacles.
原发性脑肿瘤是当代研究的一个重要焦点。随着技术的进步以及通过新型诊断方法对病例检测的增加，创新疗法和化疗方法不断涌现。本文探讨了胶质母细胞瘤化疗的最新进展，重点介绍了提供有价值机制见解的创新方法。它深入研究了神经胶质瘤新兴疗法的作用机制、分子靶点和未来潜力。此外，本文还概述了一系列疗法的研究，包括各种化疗药物、嵌合抗原受体T细胞（CAR-T）疗法、针对细胞呼吸的药物以及其他方法。此外，本文还讨论了化疗相关的挑战，包括血脑屏障、耐药性和免疫抑制，同时提出了克服这些障碍的潜在解决方案。
