Lubas George, Paltrinieri Saverio, Papini Roberto Amerigo, Lensi Ilaria, Benali Silvia, Cortadellas Oscar, Fondati Alessandra, Roura Xavier, Zini Eric
Clinica Veterinaria Colombo, VetPartners Italia, V.le Colombo 153, Lido di Camaiore, 55041 Lucca, Italy.
Department of Veterinary Medicine and Animal Sciences, University of Milan, Via dell'Università 6, 26900 Lodi, Italy.
Animals (Basel). 2025 Jun 10;15(12):1716. doi: 10.3390/ani15121716.
The erythrocyte sedimentation rate (ESR) is used in canine medicine in several disorders, especially to evaluate the levels of inflammation. ESR is a valid inflammatory marker in canine leishmaniosis (CanL), being markedly increased in sick dogs. This study evaluated the ESR together with several other inflammatory and immune response markers in 43 dogs affected by severe leishmaniosis, treated with antileishmanial treatment. Dogs were monitored at the beginning (T1) of treatment, in the middle (T2) of treatment, and 7-10 days after the end of the treatment (T3). The antileishmanial treatment was based on meglumine antimoniate and allopurinol for four weeks plus adding prednisolone at the anti-inflammatory dosage progressively tapered within the T2 set point. The ESR was measured and compared to immune and/or inflammatory markers (C-reactive protein, fibrinogen, ferritin, gamma-globulins, IgG). ESR levels were statistically reduced during treatment and significantly decreased at the end of the treatment. This came along with an improvement in other blood markers. This study shows the utility of ESR as a point-of-care test that can be used to monitor the response of dogs to antileishmanial treatment.
红细胞沉降率（ESR）在犬类医学中用于多种病症，尤其用于评估炎症水平。ESR是犬利什曼病（CanL）的一种有效的炎症标志物，患病犬的ESR会显著升高。本研究评估了43只患有严重利什曼病且接受抗利什曼治疗的犬的ESR以及其他几种炎症和免疫反应标志物。在治疗开始时（T1）、治疗中期（T2）以及治疗结束后7 - 10天（T3）对犬进行监测。抗利什曼治疗基于葡甲胺锑酸盐和别嘌呤醇持续四周，再加上在T2设定点内逐渐减量至抗炎剂量的泼尼松龙。测量ESR并与免疫和/或炎症标志物（C反应蛋白、纤维蛋白原、铁蛋白、γ球蛋白、IgG）进行比较。治疗期间ESR水平在统计学上有所降低，治疗结束时显著下降。这伴随着其他血液标志物的改善。本研究表明ESR作为一种即时检验方法，可用于监测犬对抗利什曼治疗的反应。
