Mozduri Zohre, Plastow Graham, Dekkers Jack, Houlahan Kerry, Kemp Robert, Juárez Manuel
Livestock Gentec Centre, Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, AB T6G 2E1, Canada.
Department of Animal Science, Iowa State University, Ames, IA 50011, USA.
Animals (Basel). 2025 Jun 13;15(12):1754. doi: 10.3390/ani15121754.
This study identified genomic variants and potential candidate genes associated with 11 primal cut traits (back fat, belly fat, total fat, loin fat, ham fat, picnic fat, butt fat, loin intramuscular fat content, ham side fat, shoulder dorsal fat, and belly side fat thicknesses) in Canadian commercial crossbred pigs. Genome-wide association studies using whole genome sequencing data were conducted using genotyping data from 1118 commercial crossbred pigs. This analysis revealed multiple QTLs across chromosomes SSC1, 2, 3, 6, 7, 9, 14, 15, and 17, associated with fat traits. Notably, an SNP at position 160,230,075 bp on SSC1 was significantly associated with multiple fat traits, including belly fat, butt fat, ham fat, loin fat, picnic fat, and side fat. Common genes in windows associated with multiple traits, such as , , and were shared across these traits, suggesting pleiotropic effects. Some of the QTLs were near previously identified QTLs or candidate genes that have been reported to be linked to meat quality traits associated with backfat and intramuscular fat. Other candidate genes identified in the study include , , and genes from the family, highlighting their roles in fat deposition and composition. Additional candidate genes were also implicated in regulation of fat metabolism, adipogenesis, and adiposity. These findings offer valuable insights into the genetic architecture of fat traits in pigs, which could inform breeding strategies aimed at improving the pork quality.
本研究鉴定了与加拿大商业杂交猪11种主要分割部位性状（背膘、腹脂、总脂肪、腰肉脂肪、火腿脂肪、野餐肉脂肪、臀脂、腰肉肌内脂肪含量、火腿侧脂肪、肩背脂肪和腹侧脂肪厚度）相关的基因组变异和潜在候选基因。利用1118头商业杂交猪的基因分型数据，对全基因组测序数据进行了全基因组关联研究。该分析揭示了跨越猪1号、2号、3号、6号、7号、9号、14号、15号和17号染色体的多个与脂肪性状相关的数量性状基因座（QTL）。值得注意的是，猪1号染色体上160,230,075 bp位置的一个单核苷酸多态性（SNP）与多个脂肪性状显著相关，包括腹脂、臀脂、火腿脂肪、腰肉脂肪、野餐肉脂肪和侧脂肪。与多个性状相关的窗口中的常见基因，如[此处原文缺失具体基因名称]、[此处原文缺失具体基因名称]和[此处原文缺失具体基因名称]，在这些性状中共享，表明存在多效性效应。一些QTL靠近先前鉴定的QTL或候选基因，这些基因已被报道与与背膘和肌内脂肪相关的肉质性状有关。该研究中鉴定的其他候选基因包括[此处原文缺失具体基因名称]、[此处原文缺失具体基因名称]和来自[此处原文缺失具体基因家族名称]家族的基因，突出了它们在脂肪沉积和组成中的作用。其他候选基因也参与了脂肪代谢、脂肪生成和肥胖的调节。这些发现为猪脂肪性状的遗传结构提供了有价值的见解，可为旨在改善猪肉品质的育种策略提供参考。
