早发性脊柱侧弯的最终融合策略:磁控生长棒治疗后植入物密度有影响吗?

Final Fusion Strategies in Early-Onset Scoliosis: Does Implant Density Make a Difference After Magnetically Controlled Growing Rod Treatment?

作者信息

Brigato Paolo, Oggiano Leonardo, De Salvatore Sergio, Palombi Davide, Sessa Sergio, Longo Umile Giuseppe, Vescio Andrea, Costici Pier Francesco

机构信息

Research Unit of Orthopaedic and Trauma Surgery, Department of Medicine and Surgery, Università Campus Bio-Medico di Roma, Via Alvaro del Portillo, 21-00128 Rome, Italy.

Fondazione Policlinico Universitario Campus Bio-Medico, Via Alvaro del Portillo, 200-00128 Roma, Italy.

出版信息

Children (Basel). 2025 May 31;12(6):731. doi: 10.3390/children12060731.

Abstract

BACKGROUND/OBJECTIVES: Early-onset scoliosis (EOS) frequently requires growth-friendly interventions, such as magnetically controlled growing rods (MCGRs), followed by definitive spinal fusion upon skeletal maturity. The optimal implant density (ID) for final posterior spinal fusion in these patients remains controversial. This study aimed to compare the radiographic, surgical, and economic outcomes associated with high-density (HD) versus low-density (LD) screw constructs in EOS patients previously treated with MCGRs undergoing definitive fusion.

METHODS

This retrospective study included 27 EOS patients who underwent definitive posterior spinal fusion between January 2017 and September 2022. Participants were categorized into two groups: HD (n = 13) and LD (n = 14). Primary outcomes included coronal and sagittal radiographic parameters assessed at early postoperative and final follow-up visits (minimum of 2 years). The secondary outcomes analyzed were major postoperative complications (grade ≥ IIIB according to Clavien-Dindo-Sink Classification [CDSC]), operative time, blood loss, hospital stay length, and total implant costs.

RESULTS

Baseline characteristics between the HD and LD groups were comparable. Early postoperative radiographic assessment demonstrated significantly greater thoracic kyphosis (16.3 ± 7.6° vs. 10.9 ± 14.4°, = 0.021) and T1-S1 spinal height (43.3 ± 6.7 mm vs. 39.1 ± 4.3 mm, = 0.039) in the HD group. At final follow-up, only T1-S1 spinal height remained significantly higher in the HD group (45.4 ± 7 mm vs. 39.7 ± 5.1 mm, = 0.021). Implant costs were significantly higher in the HD group (EUR 6046.5 ± 1146.9 vs. EUR 4376.4 ± 999.4, < 0.001), while operative time, blood loss, and hospital stay length showed no significant differences. HD constructs had three major complications requiring surgical revision, whereas LD constructs reported no perioperative complications but experienced three late-onset complications also necessitating revision surgery.

CONCLUSIONS

LD constructs provided comparable long-term radiographic and clinical outcomes to HD constructs, with significantly lower implant-related costs. Despite initial superior kyphosis correction in HD constructs, this benefit diminished by the final follow-up. These findings support a selective, lower-density screw placement strategy to minimize costs and surgical complexity without compromising patient outcomes in EOS undergoing definitive spinal fusion.

摘要

背景/目的:早发性脊柱侧弯(EOS)通常需要采用对生长有益的干预措施,如磁控生长棒(MCGRs),并在骨骼成熟后进行确定性脊柱融合术。这些患者最终后路脊柱融合的最佳植入物密度(ID)仍存在争议。本研究旨在比较接受MCGRs治疗后进行确定性融合的EOS患者中,高密度(HD)与低密度(LD)螺钉结构在影像学、手术及经济方面的结果。

方法

这项回顾性研究纳入了2017年1月至2022年9月期间接受确定性后路脊柱融合术的27例EOS患者。参与者分为两组:HD组(n = 13)和LD组(n = 14)。主要结局包括术后早期及最终随访(至少2年)时评估的冠状面和矢状面影像学参数。分析的次要结局为术后主要并发症(根据Clavien-Dindo-Sink分类法[CDSC]为≥IIIB级)以及手术时间、失血量、住院时间和植入物总费用。

结果

HD组和LD组的基线特征具有可比性。术后早期影像学评估显示,HD组的胸椎后凸明显更大(16.3±7.6°对10.9±14.4°,P = 0.021),T1-S1脊柱高度更高(43.3±6.7 mm对39.1±4.3 mm,P = 0.039)。在最终随访时,仅HD组的T1-S1脊柱高度仍显著更高(45.4±7 mm对39.7±5.1 mm,P = 0.021)。HD组的植入物成本显著更高(6046.5±1146.9欧元对4376.4±999.4欧元,P < 0.001),而手术时间、失血量和住院时间无显著差异。HD结构有3例需要手术翻修的主要并发症,而LD结构报告无围手术期并发症,但有3例迟发性并发症也需要翻修手术。

结论

LD结构在长期影像学和临床结果方面与HD结构相当,且植入物相关成本显著更低。尽管HD结构在初始时对后凸矫正更优,但到最终随访时这种优势减弱。这些发现支持一种选择性的、低密度螺钉置入策略,以在不影响接受确定性脊柱融合术的EOS患者结局的情况下,将成本和手术复杂性降至最低。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2654/12190953/f70a66828589/children-12-00731-g001.jpg

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