Viebahn-Haensler Renate, León Fernández Olga Sonia
Medical Society for the Use of Ozone in Prevention and Therapy, Iffezheim, D-76473 Baden-Baden, Germany.
Pharmacy and Food Institute, University of Havana, Calle 222 # 2317 e/23 y 31, Coronela, Lisa, Havana 10 400, Cuba.
Int J Mol Sci. 2025 Jun 10;26(12):5557. doi: 10.3390/ijms26125557.
Ischemia-reperfusion (I/R) damage remains a major problem in surgery, primarily based on high oxidative stress generated during the reperfusion process. Mitochondria are significantly affected, their metabolic and energetic processes are impaired, and the redox system is out of balance. Regulation and restoration of the redox balance by oxidative preconditioning with ozone is being investigated worldwide in cell and animal models. Selected preclinical trials and their results, with a focus on cardiological and neuronal I/R damage, are presented and discussed. We regularly find an upregulation of antioxidants, demonstrated in SOD (superoxide dismutase) and GSH (glutathione, reduced form, and a decrease in oxidative stress as a result, shown here using the typical stress parameters, MDA (malondialdehyde) and TBARS (thiobarbituric acid reactive substances). Mitochondrial biogenesis, comparable to moderate physical activity, is induced by ozone oxidative preconditioning in an I/R model in rats and reviewed in this paper.
缺血再灌注（I/R）损伤仍然是外科手术中的一个主要问题，主要是由于再灌注过程中产生的高氧化应激。线粒体受到显著影响，其代谢和能量过程受损，氧化还原系统失衡。在细胞和动物模型中，全球范围内正在研究通过臭氧氧化预处理来调节和恢复氧化还原平衡。本文介绍并讨论了选定的临床前试验及其结果，重点关注心脏和神经元的I/R损伤。我们经常发现抗氧化剂上调，如超氧化物歧化酶（SOD）和谷胱甘肽（还原型谷胱甘肽）所示，并且由此导致氧化应激降低，这里使用典型的应激参数丙二醛（MDA）和硫代巴比妥酸反应性物质（TBARS）来表明。在大鼠的I/R模型中，臭氧氧化预处理可诱导线粒体生物发生，类似于适度的体育活动，本文对此进行了综述。
