: Optimal coping with chronic pain (CP) has a positive impact on minimizing the barriers to patients' quality of life. Mindfulness-based approaches have been shown to improve emotional regulation and coping strategies in CP management, promoting a greater acceptance of pain and reducing psychological distress. Given that personality traits may influence the adjustment to chronic pain, this study aimed to investigate whether specific personality dimensions, based on Cloninger's model of temperament-character dimensions, affect the enrolment and the response to pain treatment in an innovative hybrid arts-based CBT-CP group intervention for patients with non-malignant CP. : A pre-and-post assessment design was implemented in a non-randomized control trial. A total number of 100 outpatients at a University Pain Management Unit were allocated through self-selection in either an arts-based CBT-CP group intervention ( = 50) or a treatment-as-usual (TAU) control group ( = 50). All participants completed the Brief Pain Inventory (BPI), the Orbach and Mikulincer Mental Pain Scale (OMMP), the Tolerance for Mental Pain Scale (TMPS), and the Temperament and Character Inventory (TCI-140). The assessment took place at baseline and at the end of the intervention, after a 10-week period. The statistical analyses included a -test for independent samples, Chi-square, and linear regression analyses. : At baseline, the arts-based CBT-CP intervention group had a higher score in the novelty seeking character dimension ( = 64.04; = 9.56), whereas the TAU group was found to have higher scores in self-directedness ( = 74.34; = 11.22) and self-transcendence ( = 51.42; = 6.61). The arts-based CBT-CP group reported a lower loss of control ( = 22.94; = 6.70) and higher belief in the ability to cope with pain ( = 21.10; = 3.76) after the intervention, compared to the control group. Self-transcendence was found to be a significant predictor of average pain as well as of patients' belief in their ability to cope with pain. : The current study provides practice-based evidence suggesting that an arts-based CBT-CP group intervention is a promising treatment for non-malignant CP. Personality dimensions affect patients' enrolment and response to pain treatment. Furthermore, integrating mindfulness-based strategies within such interventions may further enhance treatment outcomes by fostering acceptance, improving coping mechanisms, and reducing the emotional burden associated with chronic pain.