Chen Xi, Han Xue, Chen Mianhong, Li Jihua, Zhou Wei, Li Ruyi
School of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin 150001, China.
Key Laboratory of Tropical Crop Products Processing of Ministry of Agriculture and Rural Affairs, Agricultural Products Processing Research Institute, Chinese Academy of Tropical Agricultural Sciences, Zhanjiang 524001, China.
Foods. 2025 Jun 10;14(12):2047. doi: 10.3390/foods14122047.
The growing prevalence of obesity poses a significant challenge to public health. This research explored the impact of oat protein isolate (OPI) on mitigating obesity induced by a high-fat diet (HFD) in rats. The results indicate that OPI, administered at a dose of 100 mg/kg, reduced the gain of body weight and fat deposits, ameliorated glucose metabolism, promoted antioxidant capacity, and alleviated inflammation. Results from the 16S rRNA sequencing of fecal samples reveal that OPI mitigated the gut microbiota disorder induced by an HFD, significantly raising the proportion of beneficial genera, such as , , , , and . Furthermore, OPI promoted the growth of beneficial bacteria, elevated the production of short-chain fatty acid (SCFAs), and improved glucose and lipid metabolism and reduced inflammation, collectively contributing to its anti-obesity effects. These findings confirm OPI's efficacy in reducing obesity induced by an HFD in rats. Future clinical trials are needed to further validate the efficacy of OPI as a functional food.
肥胖患病率的不断上升对公共卫生构成了重大挑战。本研究探讨了燕麦分离蛋白（OPI）对减轻高脂饮食（HFD）诱导的大鼠肥胖的影响。结果表明，以100 mg/kg的剂量施用OPI可降低体重增加和脂肪沉积，改善葡萄糖代谢，提高抗氧化能力，并减轻炎症。粪便样本的16S rRNA测序结果显示，OPI减轻了HFD诱导的肠道微生物群紊乱，显著提高了有益菌属的比例，如 、 、 、 和 。此外，OPI促进了有益细菌的生长，提高了短链脂肪酸（SCFAs）的产生，并改善了葡萄糖和脂质代谢，减轻了炎症，共同促成了其抗肥胖作用。这些发现证实了OPI在减轻大鼠HFD诱导的肥胖方面的功效。未来需要进行临床试验，以进一步验证OPI作为功能性食品的功效。
