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燕麦分离蛋白通过调节肠道微生物群、血糖和脂质水平减轻高脂饮食诱导的大鼠肥胖。

Oat Protein Isolate Mitigates High-Fat Diet-Induced Obesity in Rats Through Gut Microbiota, Glucose, and Lipid Control.

作者信息

Chen Xi, Han Xue, Chen Mianhong, Li Jihua, Zhou Wei, Li Ruyi

机构信息

School of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin 150001, China.

Key Laboratory of Tropical Crop Products Processing of Ministry of Agriculture and Rural Affairs, Agricultural Products Processing Research Institute, Chinese Academy of Tropical Agricultural Sciences, Zhanjiang 524001, China.

出版信息

Foods. 2025 Jun 10;14(12):2047. doi: 10.3390/foods14122047.

DOI:10.3390/foods14122047
PMID:40565656
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12192181/
Abstract

The growing prevalence of obesity poses a significant challenge to public health. This research explored the impact of oat protein isolate (OPI) on mitigating obesity induced by a high-fat diet (HFD) in rats. The results indicate that OPI, administered at a dose of 100 mg/kg, reduced the gain of body weight and fat deposits, ameliorated glucose metabolism, promoted antioxidant capacity, and alleviated inflammation. Results from the 16S rRNA sequencing of fecal samples reveal that OPI mitigated the gut microbiota disorder induced by an HFD, significantly raising the proportion of beneficial genera, such as , , , , and . Furthermore, OPI promoted the growth of beneficial bacteria, elevated the production of short-chain fatty acid (SCFAs), and improved glucose and lipid metabolism and reduced inflammation, collectively contributing to its anti-obesity effects. These findings confirm OPI's efficacy in reducing obesity induced by an HFD in rats. Future clinical trials are needed to further validate the efficacy of OPI as a functional food.

摘要

肥胖患病率的不断上升对公共卫生构成了重大挑战。本研究探讨了燕麦分离蛋白（OPI）对减轻高脂饮食（HFD）诱导的大鼠肥胖的影响。结果表明，以100 mg/kg的剂量施用OPI可降低体重增加和脂肪沉积，改善葡萄糖代谢，提高抗氧化能力，并减轻炎症。粪便样本的16S rRNA测序结果显示，OPI减轻了HFD诱导的肠道微生物群紊乱，显著提高了有益菌属的比例，如 、 、 、 和 。此外，OPI促进了有益细菌的生长，提高了短链脂肪酸（SCFAs）的产生，并改善了葡萄糖和脂质代谢，减轻了炎症，共同促成了其抗肥胖作用。这些发现证实了OPI在减轻大鼠HFD诱导的肥胖方面的功效。未来需要进行临床试验，以进一步验证OPI作为功能性食品的功效。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d3b9/12192181/e8b6beb9b0d9/foods-14-02047-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d3b9/12192181/b2ed26f6cbee/foods-14-02047-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d3b9/12192181/fe762d0c39eb/foods-14-02047-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d3b9/12192181/aba6f271e605/foods-14-02047-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d3b9/12192181/9838691fb8f5/foods-14-02047-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d3b9/12192181/68e5d49892b7/foods-14-02047-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d3b9/12192181/44b1a42c552c/foods-14-02047-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d3b9/12192181/4619de36bbc2/foods-14-02047-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d3b9/12192181/0acd4ab5c5f4/foods-14-02047-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d3b9/12192181/4a06dbaed39e/foods-14-02047-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d3b9/12192181/f2d199f2972e/foods-14-02047-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d3b9/12192181/e8b6beb9b0d9/foods-14-02047-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d3b9/12192181/b2ed26f6cbee/foods-14-02047-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d3b9/12192181/fe762d0c39eb/foods-14-02047-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d3b9/12192181/aba6f271e605/foods-14-02047-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d3b9/12192181/9838691fb8f5/foods-14-02047-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d3b9/12192181/68e5d49892b7/foods-14-02047-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d3b9/12192181/44b1a42c552c/foods-14-02047-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d3b9/12192181/4619de36bbc2/foods-14-02047-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d3b9/12192181/0acd4ab5c5f4/foods-14-02047-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d3b9/12192181/4a06dbaed39e/foods-14-02047-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d3b9/12192181/f2d199f2972e/foods-14-02047-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d3b9/12192181/e8b6beb9b0d9/foods-14-02047-g011.jpg

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[1]
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Int J Biol Macromol. 2025-5

[2]
Amur linden honey and its principal polyphenols alleviate obesity and regulate gut microbiota in high-fat diet-induced mice.

Food Chem X. 2025-3-14

[3]
Fabrication of tannins and oat protein non-covalent complexes: Effect on the structure and in vitro digestion properties of oat proteins.

Int J Biol Macromol. 2025-4

[4]
Anti-obesity and gut microbiota modulation effects of chondroitin sulfate on obese mice induced by high-fat diet.

Int J Biol Macromol. 2025-4

[5]
In Vitro Evaluation of Probiotic Activities and Anti-Obesity Effects of EF-1 in Mice Fed a High-Fat Diet.

Foods. 2024-12-18

[6]
Ultrasound-assisted modification of oat protein isolates: Structural and functional enhancements.

Ultrason Sonochem. 2025-1

[7]
Wheat β-glucan reduces obesity and hyperlipidemia in mice with high-fat and high-salt diet by regulating intestinal flora.

Int J Biol Macromol. 2025-2

[8]
MNAM enhances Blautia abundance and modulates Th17/Treg balance to alleviate diabetes in T2DM mice.

Biochem Pharmacol. 2024-12

[9]
Seed Oil Reduces the Severity of Colitis Induced by Dextran Sulfate Sodium by Modulating the Intestinal Microbiota and Restoring the Intestinal Barrier.

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[10]
Effects of Tea Seed Oil Extracted by Different Refining Temperatures on the Intestinal Microbiota of High-Fat-Diet-Induced Obese Mice.

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