Białomyzy Agnieszka, Kotrych Katarzyna, Bogacz Anna, Podralska Marta, Górska Aleksandra, Białecki Jacek, Uzar Izabela, Czerny Bogusław, Kamiński Adam
Eter Med Medical Center Gdansk, Żabi Kruk 10, 80-822 Gdansk, Poland.
Department and Clinic of General Endocrine Surgery and Gastrointestinal Oncology, Poznan University of Medical Sciences, Przybyszewskiego 49, 60-355 Poznan, Poland.
J Clin Med. 2025 Jun 6;14(12):4017. doi: 10.3390/jcm14124017.
Diabetes, as one of the most common diseases of civilization, is a significant factor of mortality worldwide. Undiagnosed and improperly treated, it leads to the development of a number of complications, including diabetic foot syndrome (DFS) and Charcot neuroarthropathy (CN). Charcot neuroarthropathy is a complex and devastating disease characterized by the presence of neuropathy, progressive deformities, and joint destruction. Risk factors and epidemiological data emphasize the high prevalence of CN in the diabetic population, drawing attention to typical predisposing factors for the development of this disease. Serious complications, such as foot ulcers or amputations, show the scale of the negative impact of CN and DFS on the quality of life of patients. : The aim of the study was to assess the treatment of foot ulcers in patients with DFS and CN using ozone therapy with simultaneous negative pressure wound therapy (NPWT). : The study included 30 patients aged 39 to 87 years with DFS and 30 patients with CN. Ozone therapy and negative pressure wound therapy were used for the treatment of chronic wounds. : The analysis of the results showed a significant reduction in the wound size in both study groups; in patients with DFS, a reduction from 5 cm to 0.40 cm observed after 3 weeks and to 0.002 cm after 6 weeks of therapy, while in patients with CN, a reduction from 8 cm to 1.50 cm was observed after 3 weeks and to 0.004 cm after 6 weeks of therapy. No statistically significant differences were observed in median wound sizes between the DFS and CN groups. Ozone therapy with a value of 70 μg/mL is an effective method in the treatment of chronic diseases of soft tissue and the skeletal system. In combination with NPWT after cleansing the wound of bone sequestrum, the process increased the density of capillaries by accelerating the synthesis of proteins and collagen and reduced bacterial colonization in the wound. The use of ozone therapy procedures at 70 μg/mL with negative pressure therapy is effective in the prevention and treatment of infectious bone complications in diabetes, such as diabetic foot syndrome and Charcot neuroarthropathy.
糖尿病作为文明社会中最常见的疾病之一，是全球范围内一个重要的死亡因素。若未被诊断及治疗不当，它会引发多种并发症，包括糖尿病足综合征（DFS）和夏科氏神经关节病（CN）。夏科氏神经关节病是一种复杂且具有破坏性的疾病，其特征为存在神经病变、进行性畸形和关节破坏。风险因素及流行病学数据凸显了CN在糖尿病患者群体中的高患病率，这使得人们关注该疾病发生的典型诱发因素。诸如足部溃疡或截肢等严重并发症，显示出CN和DFS对患者生活质量的负面影响程度。本研究的目的是评估采用臭氧疗法并同时结合负压伤口治疗（NPWT）来治疗DFS和CN患者足部溃疡的效果。该研究纳入了30名年龄在39至87岁的DFS患者以及30名CN患者。臭氧疗法和负压伤口疗法被用于治疗慢性伤口。结果分析显示，两个研究组的伤口大小均显著减小；在DFS患者中，治疗3周后伤口大小从5厘米减小至0.40厘米，治疗6周后减小至0.002厘米，而在CN患者中，治疗3周后伤口大小从8厘米减小至1.50厘米，治疗6周后减小至0.004厘米。DFS组和CN组之间的伤口大小中位数未观察到统计学上的显著差异。浓度为70μg/mL的臭氧疗法是治疗软组织和骨骼系统慢性疾病的有效方法。在清除伤口骨痂后与NPWT联合使用，该过程通过加速蛋白质和胶原蛋白的合成增加了毛细血管密度，并减少了伤口中的细菌定植。使用浓度为70μg/mL的臭氧疗法程序结合负压疗法可有效预防和治疗糖尿病中的感染性骨并发症，如糖尿病足综合征和夏科氏神经关节病。
