Kök Mehmet, Dolu Süleyman, Arayici Mehmet Emin, Köker Gökhan, Koç Lütfullah Zahit, Cekin Ayhan Hilmi
Department of Internal Medicine, University of Health Sciences, Antalya Training and Research Hospital, Antalya 07100, Turkey.
Department of Gastroenterology, Faculty of Medicine, Dokuz Eylül University, Izmir 35340, Turkey.
J Clin Med. 2025 Jun 8;14(12):4056. doi: 10.3390/jcm14124056.
Hypolipidemia has been shown to be a factor that elevates the risk of bleeding. This study aimed to investigate the relationship between cholesterol levels and the risk of peptic ulcer bleeding (PUB). : A total of 15,547 patients who underwent esophagogastroduodenoscopy (EGD) between May 2017 and December 2020 were screened. Of these, 317 were included in this retrospective cohort study. PUB was diagnosed by EGD. Serum cholesterol levels were measured at six-month intervals, and cumulative mean cholesterol concentrations were calculated using all available data during the observation period. : Ulcer bleeding was detected in 173 (45.6%) patients with peptic ulcer. Patients with bleeding peptic ulcer exhibited significantly lower TC, LDL-C, and HDL-C levels compared to non-bleeding peptic ulcer patients and controls ( < 0.001). The optimal LDL cut-off was 91.50 ( < 0.001), with 75.1% sensitivity and 24.1% specificity. For HDL, the cut-off was 42.50 ( < 0.001), yielding 72.3% sensitivity and 30.1% specificity. A one-unit increase in LDL and HDL reduced the risk of PUB by 0.95-fold and 0.97-fold, respectively. : Our findings suggest that reduced cholesterol levels, particularly LDL-C and HDL-C, may elevate the risk of PUB. Therefore, monitoring cholesterol levels in peptic ulcer patients, especially those at higher bleeding risk, could be beneficial.
低血脂已被证明是增加出血风险的一个因素。本研究旨在调查胆固醇水平与消化性溃疡出血（PUB）风险之间的关系。：对2017年5月至2020年12月期间接受食管胃十二指肠镜检查（EGD）的15547例患者进行了筛查。其中，317例被纳入这项回顾性队列研究。通过EGD诊断PUB。每隔六个月测量血清胆固醇水平，并使用观察期内所有可用数据计算累积平均胆固醇浓度。：在173例（45.6%）消化性溃疡患者中检测到溃疡出血。与非出血性消化性溃疡患者和对照组相比，出血性消化性溃疡患者的总胆固醇（TC）、低密度脂蛋白胆固醇（LDL-C）和高密度脂蛋白胆固醇（HDL-C）水平显著更低（<0.001）。最佳LDL切点为91.50（<0.001），敏感性为75.1%，特异性为24.1%。对于HDL，切点为42.50（<0.001），敏感性为72.3%，特异性为30.1%。LDL和HDL每增加一个单位，PUB风险分别降低0.95倍和0.97倍。：我们的研究结果表明，胆固醇水平降低，尤其是LDL-C和HDL-C，可能会增加PUB的风险。因此，监测消化性溃疡患者的胆固醇水平，尤其是出血风险较高的患者，可能是有益的。
