Kim Eunjoo, Woo Wongi, Lee Sungsoo, Kang Hee-Taik
Department of Psychology, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul 06273, Republic of Korea.
Department of Internal Medicine, Dignity Health St. Joseph's Medical Center Stockton, Stockton, CA 95204, USA.
J Clin Med. 2025 Jun 9;14(12):4070. doi: 10.3390/jcm14124070.
Patients with cancer often experience severe mental distress, and suicide is an important issue, particularly prevalent in individuals with lung cancer. The present study aimed to investigate the longitudinal incidence of suicide among patients with lung cancer using national registry data. A population-based retrospective review of patients diagnosed with lung cancer in 2008 was conducted. Longitudinal medical records, including clinical outcomes and medical insurance data, were investigated. The primary outcome was the incidence of suicide, compared between patients undergoing the first curative treatment option (surgery or non-surgery). Cox proportional hazard regression models were used to adjust for medical history, sociodemographic variables, and lifestyle factors. : Among the 4495 patients included, 1306 (29.1%) underwent surgery as the first treatment. Compared to the non-surgery group, the surgery group was younger and had a lower Charlon comorbidity score ( < 0.001), higher physical activity ( < 0.001), and higher income level ( < 0.001). The total number of suicides was 28 (0.62%). The surgery group demonstrated similar trends in the development of suicide and early 5-year follow-up to those of the non-surgery group. The longitudinal risk of suicide among patients with lung cancer increased. Both surgical and non-surgical treatment groups demonstrated similar suicide trends, although patients in the surgery group had multiple protective factors.
癌症患者常经历严重的精神困扰，自杀是一个重要问题，在肺癌患者中尤为普遍。本研究旨在利用国家登记数据调查肺癌患者自杀的纵向发生率。对2008年诊断为肺癌的患者进行了基于人群的回顾性研究。调查了包括临床结局和医疗保险数据在内的纵向医疗记录。主要结局是自杀发生率，比较接受第一种根治性治疗方案（手术或非手术）的患者。采用Cox比例风险回归模型对病史、社会人口统计学变量和生活方式因素进行校正。在纳入的4495例患者中，1306例（29.1%）接受手术作为首次治疗。与非手术组相比，手术组患者年龄更小，Charlon合并症评分更低（<0.001），身体活动水平更高（<0.001），收入水平更高（<0.001）。自杀总数为28例（0.62%）。手术组在自杀发生和5年早期随访方面与非手术组表现出相似趋势。肺癌患者自杀的纵向风险增加。手术和非手术治疗组均表现出相似的自杀趋势，尽管手术组患者有多种保护因素。
