Junejo Shoaib, Chen Mengxuan, Ali Muhammad Usman, Ratnam Shobha, Malhotra Deepak, Gong Rujun
Division of Nephrology, University of Toledo College of Medicine, Toledo, OH 43614, USA.
J Clin Med. 2025 Jun 11;14(12):4144. doi: 10.3390/jcm14124144.
Chronic kidney disease (CKD) is a major global public health issue, affecting over 690 million individuals worldwide. The prevalence, diagnosis, and treatment of kidney disease vary considerably across different geographical regions. However, comprehensive and in-depth research on CKD remains limited due to its diverse etiologies. This study provides a detailed assessment of the disease burden of CKD, considering its etiological basis and utilizing the latest data reflecting changing trends. This research synthesizes findings from previous studies, with the necessary literature sourced from online platforms such as Google Scholar, EMBASE, and PubMed/MEDLINE databases, as well as Global Burden of Disease (GBD), to compare visualizations of the world's CKD levels and trends from 1990 to 2021. The study results demonstrated that eating patterns are affected by historical and industrial factors, which likely contribute to the high prevalence of CKD in Western countries. The data also indicated that the global number of new CKD cases increased from just over 7.8 million in 1990 to nearly 19 million after 30 years. Additionally, the results showed that age and sex together accounted for the observed prevalence and disease-attributable disability-adjusted life year (DALY) rates in CKD, with the highest rates seen in older age groups, except for CKD attributed to type 1 diabetes, where the incidence was higher in children, and the burden was greater in middle-aged adults. Overall, these findings are a valuable addition to the existing literature and provide evidence that CKD studies over a similar time frame reveal notable global trends and regional differences in highlighting this increasing burden.
慢性肾脏病(CKD)是一个重大的全球公共卫生问题,全球有超过6.9亿人受其影响。不同地理区域的肾脏疾病患病率、诊断和治疗情况差异很大。然而,由于其病因多样,对CKD的全面深入研究仍然有限。本研究基于CKD的病因基础,利用反映变化趋势的最新数据,对CKD的疾病负担进行了详细评估。本研究综合了以往研究的结果,必要的文献来源于谷歌学术、EMBASE和PubMed/MEDLINE数据库等在线平台以及全球疾病负担(GBD),以比较1990年至2021年全球CKD水平和趋势的可视化情况。研究结果表明,饮食模式受历史和产业因素影响,这可能是西方国家CKD患病率高的原因。数据还显示,全球新增CKD病例数从1990年的略高于780万例增加到30年后的近1900万例。此外,结果表明年龄和性别共同影响了CKD的观察患病率和疾病归因伤残调整生命年(DALY)率,除1型糖尿病导致的CKD外,老年人群体的发病率最高,1型糖尿病导致的CKD儿童发病率较高,中年成年人的负担更大。总体而言,这些发现是对现有文献的宝贵补充,并提供了证据表明,在类似时间框架内的CKD研究揭示了这一日益加重负担方面显著的全球趋势和区域差异。