Kim Heesuk, Park Ji Eun, Choi Wungrak
Institute of Vision Research, Department of Ophthalmology, Yonsei University College of Medicine, Seoul 03722, Republic of Korea.
Yonsei University College of Medicine, Seoul 03722, Republic of Korea.
J Clin Med. 2025 Jun 15;14(12):4258. doi: 10.3390/jcm14124258.
The purpose of this study was to evaluate the diagnostic accuracy of glaucoma by establishing normative data on retinal nerve fiber layer (RNFL) thickness, specifically for healthy Koreans, using Huvitz spectral-domain optical coherence tomography (OCT). This study also aimed to compare the obtained RNFL thickness data with normative values provided by the Cirrus OCT system to identify any device-specific differences that could impact glaucoma diagnosis. : This prospective observational study included 148 healthy participants aged 20-69 years at Gangnam Severance Hospital. Participants underwent comprehensive ophthalmologic evaluations, including RNFL thickness measurements using Huvitz OCT, which were compared with existing normative Cirrus OCT data. RNFL thickness was analyzed by quadrant (superior, inferior, nasal, and temporal) and clock-hour sectors. Statistical analysis included one-way analysis of variance (ANOVA) for group comparisons and linear regression to assess age-related changes. : The average RNFL thickness was 91.13 ± 13 μm, with the thickest measurements in the superior quadrant (111.85 ± 18.53 μm) and the thinnest in the nasal quadrant (68.35 ± 20.03 μm). Significant age-related thinning was observed across all quadrants, particularly the superior and inferior quadrants. Comparison with the Cirrus OCT system revealed significant differences, with the Huvitz OCT results showing thinner RNFL in the superior and inferior quadrants. : This study established normative RNFL thickness data in healthy Koreans using Huvitz OCT, providing essential reference data for clinical glaucoma diagnosis. The differences between Huvitz and Cirrus OCT systems underscore the need for device- and population-specific normative data to improve diagnostic accuracy in glaucoma management.
本研究的目的是通过使用Huvitz光谱域光学相干断层扫描（OCT）建立视网膜神经纤维层（RNFL）厚度的规范数据，特别是针对健康韩国人，来评估青光眼的诊断准确性。本研究还旨在将获得的RNFL厚度数据与Cirrus OCT系统提供的规范值进行比较，以识别可能影响青光眼诊断的任何设备特定差异。：这项前瞻性观察性研究纳入了江南Severance医院148名年龄在20 - 69岁的健康参与者。参与者接受了全面的眼科评估，包括使用Huvitz OCT测量RNFL厚度，并将其与现有的Cirrus OCT规范数据进行比较。RNFL厚度按象限（上、下、鼻、颞）和钟点扇形区域进行分析。统计分析包括用于组间比较的单因素方差分析（ANOVA）和用于评估年龄相关变化的线性回归。：RNFL平均厚度为91.13±13μm，上象限测量值最厚（111.85±18.53μm），鼻象限最薄（68.35±20.03μm）。在所有象限中均观察到与年龄相关的显著变薄，尤其是上象限和下象限。与Cirrus OCT系统的比较显示存在显著差异，Huvitz OCT结果显示上象限和下象限的RNFL更薄。：本研究使用Huvitz OCT建立了健康韩国人的RNFL厚度规范数据，为临床青光眼诊断提供了重要的参考数据。Huvitz和Cirrus OCT系统之间的差异强调了需要特定于设备和人群的规范数据，以提高青光眼管理中的诊断准确性。
