Sungur Elif Coşkun, Benli Emre Demir, Küçüker Şeref Alp, Sarıtaş Ahmet
Department of Cardiovascular Surgery, Ministry of Health Ankara Bilkent City Hospital, Cankaya, Ankara 06800, Turkey.
J Clin Med. 2025 Jun 18;14(12):4337. doi: 10.3390/jcm14124337.
The aim of this study was to evaluate the clinical outcomes of adult patients who underwent repair for delayed isolated coarctation of the aorta (CoA). In addition, we aimed to assess the immediate results of the interventions and long-term follow-up data. A total of 119 adult patients who were operated on for CoA and remained under follow-up during a 25-year study period were retrospectively analyzed. The pre-, intra-, and postoperative data of the patients were recorded. The surgical methods applied preoperatively and/or postoperatively were classified based on the primary issue as interventions involving the aorta and those not involving the aorta. Of the patients, 81 were males and 28 were females with a mean age of 30.55 ± 10.84 (range: 18 to 67) years. The mean follow-up was 74.79 ± 61.71 (range: 0 to 271) months. A statistically significant difference was found between the presence of pre- and postoperative hypertension and the incidence of postoperative hypertension in patients under the age of 30 ( = 0.021 and = 0.039, respectively). A total of 13 patients underwent surgery for recoarctation. The overall rate of additional cardiac surgery was 11.80%. The presence of preoperative hypertension and valve morphology (normal vs. bicuspid) were found to be statistically significant for the need for surgery before and after CoA repair. Patients with repaired CoA should be closely monitored due to the lifelong risk of developing complications. In particular, we recommend annual follow-up for patients with BAV.
本研究的目的是评估接受延迟性孤立性主动脉缩窄（CoA）修复术的成年患者的临床结局。此外，我们旨在评估干预措施的即时结果和长期随访数据。对在25年研究期间接受CoA手术并仍在随访中的119例成年患者进行了回顾性分析。记录了患者术前、术中和术后的数据。根据主要问题，将术前和/或术后应用的手术方法分为涉及主动脉的干预措施和不涉及主动脉的干预措施。患者中，男性81例，女性28例，平均年龄30.55±10.84（范围：18至67）岁。平均随访时间为74.79±61.71（范围：0至271）个月。在30岁以下患者中，术前和术后高血压的存在与术后高血压的发生率之间存在统计学显著差异（分别为P = 0.021和P = 0.039）。共有13例患者接受了再缩窄手术。额外心脏手术的总体发生率为11.80%。术前高血压的存在和瓣膜形态（正常与二叶式）被发现对于CoA修复术前和术后的手术需求具有统计学显著性。由于存在发生并发症的终身风险，CoA修复术后的患者应密切监测。特别是，我们建议对患有二叶式主动脉瓣（BAV）的患者进行每年随访。
