Miles Miriam A, Akinyele Oluseun, Ninson Abigail A, Caviness-Ashe Nicole, Means Cha'Breia, Anderson-Tolbert Le'Andrea, Smith Tuchondriana, Coleman Reagan, Rogers Laura Q, Joseph Joshua J, Pinheiro Laura C, Nolan Timiya S
Department of Medicine, Division of General Internal Medicine and Population Science, University of Alabama at Birmingham, Boshell Diabetes Building, Birmingham, AL 35233, USA.
Embrace Society, 16 Otele Avenue, East Legon, Accra 233-030, Ghana.
Int J Environ Res Public Health. 2025 Jun 10;22(6):920. doi: 10.3390/ijerph22060920.
Cardiovascular disease (CVD) is the most common non-cancer cause of death among cancer survivors. Lifestyle and clinical factors associated with cancer mortality are also associated with cardiovascular mortality. The American Heart Association (AHA) has termed these factors "cardiovascular health" (CVH), using Life's Simple 7 (LS7) or "Life's Essential 8 (LE8)" to determine poor, intermediate, and high (ideal) CVH. Further, less than ideal CVH is associated with higher cancer mortality. Yet, CVH among cancer survivors remains understudied. This systematic review examined the extant literature, providing a comprehensive report of the findings addressing CVH among cancer survivors.
Using PRISMA guidelines, we systematically examined CVH among cancer survivors (including patients) within PubMed, Scopus, CINAHL, and Embase databases without date limitations from June 2024 to December 2024 using the following keywords: "cancer survivors", "cancer patient", "cardiovascular health", and "cardiovascular risk factors". Two reviewers independently accessed articles in concordance with LS7 and LE8 metrics. The included studies were examined and assessed for risk of bias and synthesized to elucidate themes of CVH among cancer survivors.
We retrieved 2935 studies examining breast, gynecological, endometrial, prostate, colon, lung, lymphoma, and skin cancer survivors published from 2002-2024. Overall, 10 studies met criteria utilizing LS7 or LE8 CVH health outcomes (4 LS7, 5 LE8, and 1 LS7/LE8), ages 40-70 years, with a population (n = 35,980) consisting of mostly female, non-Black individuals; mean survivorship was 7.2 years. Four themes emerged: CVH outcomes among cancer survivors, social factors impacting CVH outcomes, associations of CVH, and other health outcomes opportunities for CVH awareness.
We found that cancer survivors frequently report less than ideal CVH outcomes and would benefit from education/empowerment to support lifestyle changes that improve CVH.
心血管疾病（CVD）是癌症幸存者中最常见的非癌症死亡原因。与癌症死亡率相关的生活方式和临床因素也与心血管死亡率相关。美国心脏协会（AHA）将这些因素称为“心血管健康”（CVH），使用“生命简单7要素”（LS7）或“生命基本8要素”（LE8）来确定不良、中等和高（理想）CVH。此外，不理想的CVH与较高的癌症死亡率相关。然而，癌症幸存者中的CVH情况仍未得到充分研究。本系统评价对现有文献进行了审查，提供了一份关于癌症幸存者CVH研究结果的综合报告。
使用PRISMA指南，我们在PubMed、Scopus、CINAHL和Embase数据库中，于2024年6月至2024年12月期间，使用以下关键词，系统地审查了癌症幸存者（包括患者）中的CVH：“癌症幸存者”、“癌症患者”、“心血管健康”和“心血管危险因素”。两名评审员独立根据LS7和LE8指标查阅文章。对纳入的研究进行审查和偏倚风险评估，并进行综合分析，以阐明癌症幸存者中CVH的主题。
我们检索到2935项研究，这些研究涉及2002年至2024年发表的乳腺癌、妇科癌、子宫内膜癌、前列腺癌、结肠癌、肺癌、淋巴瘤和皮肤癌幸存者。总体而言，10项研究符合使用LS7或LE8 CVH健康结果的标准（4项使用LS7，5项使用LE8，1项同时使用LS7/LE8），年龄在40至70岁之间，研究对象（n = 35980）主要为女性、非黑人个体；平均生存期为7.2年。出现了四个主题：癌症幸存者中的CVH结果、影响CVH结果的社会因素、CVH的关联以及提高CVH意识的其他健康结果机会。
我们发现癌症幸存者经常报告不理想的CVH结果，通过教育/赋权来支持改善CVH的生活方式改变，他们将从中受益。
