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阿霉素-NFL-TBS.40-63肽金复合物纳米载体（阿霉素负载于NFL@金纳米颗粒）：在PANC-1/ADR人胰腺癌耐药株细胞诱导的小鼠移植瘤模型中的疗效评估

Doxorubicin-NFL-TBS.40-63 peptide Gold Complex Nanovector (DOX IN-NFL@AuNPs): Efficacy Evaluation in a mouse transplantation tumor model induced by PANC-1/ADR human pancreatic cancer resistant strain cells.

作者信息

Liu Hui, Liu Qiqian, Li Xiaowu, Boucetta Abdelkader, Eyer Joel, Spadavecchia Jolanda

机构信息

Department of Hepatobiliary Surgery, Guangdong Provincial Key Laboratory of Regional Immunity and Diseases & Carson International Cancer Center, Shenzhen University General Hospital & Shenzhen University Clinical Medical Academy Center, Shenzhen University, Shenzhen, 518083 China.

CNRS, UMR 7244, NBD-CSPBAT, Laboratoire de Chimie, Structures et Propriétés de Biomatériaux et d'Agents Thérapeutiques Université Paris 13, Sorbonne Paris Nord, Bobigny 93000, France; University Sorbonne Paris Nord; CB3S, UMR CNRS 7244, Insitut Galilée, 99 France.

出版信息

Nanotheranostics. 2025 Jun 19;9(2):186-198. doi: 10.7150/ntno.109280. eCollection 2025.

DOI:10.7150/ntno.109280
PMID:40568371
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12188537/
Abstract

The key role of the NFL-TBS.40-63 peptide (BIOT-NFL) is to target and destroy glioma cancer cells. Recently we have performed a novel peptide-hybrid-gold nanovector (BIOT-NFL-PEG-AuNPs) capable to destroy microtubule network of pancreatic cancer cells (PDAC) exhibiting a decrease of tumor index with a real anti-angiogenic effect. In order to improve the scientific background of our study, we conceived a chemotherapeutic hybrid nanovector based on gold-doxorubicin (DOX) functionalized with the NFL-TBS.40-63 peptide (BIOT-NFL) as a promising therapeutic in PDAC cancer. Mouse transplantation tumor model induced by PANC-1/ADR human pancreatic cancer resistant strain cells, was used to evaluated the therapeutic efficacy of DOX IN-NFL@AuNPs as chemotherapeutic nano-drug. Our results indicate that DOX IN-NFL@AuNPs have a great impact on the decrease of the tumor growth and decreased the tumor index with a relevant effect on cytokines and ROS levels, thus confirming the impact of DOX IN-NFL@AuNPs to boost the immune system.

摘要

NFL-TBS.40-63肽（BIOT-NFL）的关键作用是靶向并摧毁神经胶质瘤癌细胞。最近，我们制备了一种新型的肽-杂化-金纳米载体（BIOT-NFL-PEG-AuNPs），它能够破坏胰腺癌细胞（PDAC）的微管网络，使肿瘤指数降低，并具有真正的抗血管生成作用。为了提升我们研究的科学背景，我们构思了一种基于用NFL-TBS.40-63肽（BIOT-NFL）功能化的金-阿霉素（DOX）的化疗杂化纳米载体，作为一种有前景的PDAC癌症治疗药物。利用PANC-1/ADR人胰腺癌细胞耐药株诱导的小鼠移植瘤模型，来评估DOX IN-NFL@AuNPs作为化疗纳米药物的治疗效果。我们的结果表明，DOX IN-NFL@AuNPs对肿瘤生长的抑制有很大影响，降低了肿瘤指数，对细胞因子和活性氧水平有显著影响，从而证实了DOX IN-NFL@AuNPs对增强免疫系统的作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b1c3/12188537/e8c703a17053/ntnov09p0186g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b1c3/12188537/f0c35d5a276d/ntnov09p0186g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b1c3/12188537/0a74666e94d0/ntnov09p0186g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b1c3/12188537/bf3ee1933122/ntnov09p0186g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b1c3/12188537/d667c2d8c076/ntnov09p0186g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b1c3/12188537/cd5d1b8dff2f/ntnov09p0186g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b1c3/12188537/d203e1c587f2/ntnov09p0186g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b1c3/12188537/db0a1974a673/ntnov09p0186g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b1c3/12188537/e8c703a17053/ntnov09p0186g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b1c3/12188537/f0c35d5a276d/ntnov09p0186g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b1c3/12188537/0a74666e94d0/ntnov09p0186g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b1c3/12188537/bf3ee1933122/ntnov09p0186g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b1c3/12188537/d667c2d8c076/ntnov09p0186g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b1c3/12188537/cd5d1b8dff2f/ntnov09p0186g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b1c3/12188537/d203e1c587f2/ntnov09p0186g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b1c3/12188537/db0a1974a673/ntnov09p0186g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b1c3/12188537/e8c703a17053/ntnov09p0186g008.jpg

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本文引用的文献

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Stimuli-activatable nanomedicine meets cancer theranostics.刺激响应型纳米医学与癌症诊治一体化。
Theranostics. 2023 Oct 2;13(15):5386-5417. doi: 10.7150/thno.87854. eCollection 2023.
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The use of liposomes functionalized with the NFL-TBS.40-63 peptide as a targeting agent to cross the in vitro blood-brain barrier and target glioblastoma cells.使用用NFL-TBS.40-63肽功能化的脂质体作为靶向剂，以穿过体外血脑屏障并靶向胶质母细胞瘤细胞。
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Dendrimers as Nanocarriers for the Delivery of Drugs Obtained from Natural Products.树枝状大分子作为从天然产物中提取的药物递送纳米载体。
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Challenges in Diagnosis and Treatment of Pancreatic Exocrine Insufficiency among Patients with Pancreatic Ductal Adenocarcinoma.胰腺导管腺癌患者胰腺外分泌功能不全的诊断与治疗挑战
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