Grecucci Alessandro, Orsini Chiara, Lapomarda Gaia, Sorella Sara, Messina Irene
Department of Psychology and Cognitive Sciences, University of Trento, Rovereto, Italy.
Center for Medical Sciences - CISMed, University of Trento, Trento, Italy.
Neuroimage Rep. 2023 May 8;3(2):100173. doi: 10.1016/j.ynirp.2023.100173. eCollection 2023 Jun.
Despite the kraepelinian differentiation of schizophrenia and bipolar disorder, several data questioned this net subdivision and suggested a continuity between the two. An was suggested, assuming a common psychotic core between the two disorders, as well as cognitive and affective differences. The present study aimed to investigate similarities and differences between schizophrenia and bipolar disorder for what entails the affective dimension of the . A coordinate-based meta-analytic approach on neuroimaging data was applied to understand differences and similarities in the visual perception of negative stimuli in the two groups. The activation likelihood estimation analysis included 41 experiments on schizophrenia (schizophrenia versus healthy controls) and 27 experiments on bipolar disorder (bipolar versus healthy controls). Our conjunction analysis results revealed the presence of shared functional abnormalities in thalamic, parahippocampal, and basal ganglia areas, suggesting that these patients share an altered circuit responsible for a heightened elaboration of negative emotional stimuli. The subtraction analysis highlighted that the two groups present differences too. Schizophrenia patients show widespread abnormalities in limbic, temporal, sub-lobar and midbrain regions possibly involved in emotional processing and hallucinations. On the other hand, bipolar patients show alterations in frontal areas associated with emotional appraisal, regulation, and response inhibition. This study sheds light on both similarities and differences in the emotional processing of schizophrenic and bipolar patients, and may help to better characterise the affective features of these two conditions along a continuum.
尽管克雷佩林对精神分裂症和双相情感障碍进行了区分，但一些数据对这种明确的细分提出了质疑，并表明两者之间存在连续性。有人提出了一种观点，假设这两种疾病之间存在共同的精神病性核心，以及认知和情感差异。本研究旨在探讨精神分裂症和双相情感障碍在情感维度方面的异同。应用基于坐标的神经影像学数据元分析方法来了解两组在负性刺激视觉感知方面的差异和相似性。激活可能性估计分析包括41项关于精神分裂症的实验（精神分裂症患者与健康对照）和27项关于双相情感障碍的实验（双相情感障碍患者与健康对照）。我们的联合分析结果显示，丘脑、海马旁回和基底神经节区域存在共同的功能异常，这表明这些患者共享一个改变的神经回路，该回路负责对负性情绪刺激进行增强的精细加工。减法分析突出表明两组也存在差异。精神分裂症患者在可能参与情绪处理和幻觉的边缘系统、颞叶、脑叶下和中脑区域表现出广泛的异常。另一方面，双相情感障碍患者在与情绪评估、调节和反应抑制相关的额叶区域存在改变。这项研究揭示了精神分裂症和双相情感障碍患者在情绪处理方面的异同，并可能有助于更好地描述这两种疾病在连续体上的情感特征。
