Kurtz Marcel, Mohring Pia, Förster Katharina, Bauer Michael, Kanske Philipp
Clinical Psychology and Behavioral Neuroscience, Faculty of Psychology, Technische Universität Dresden, Chemnitzer Str. 46, 01187, Dresden, Germany.
Department of Psychiatry and Psychotherapy, Medical Faculty, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
Int J Bipolar Disord. 2021 May 3;9(1):15. doi: 10.1186/s40345-021-00221-9.
This study aimed to compile and synthesize studies investigating explicit emotion regulation in patients with bipolar disorder and individuals at risk of developing bipolar disorder. The importance of explicit emotion regulation arises from its potential role as a marker for bipolar disorders in individuals at risk and its potent role in therapy for bipolar disorder patients.
To obtain an exhaustive compilation of studies dealing specifically with explicit emotion regulation in bipolar disorder, we conducted a systematic literature search in four databases. In the 15 studies we included in our review, the emotion-regulation strategies maintenance, distraction, and reappraisal (self-focused and situation-focused) were investigated partly on a purely behavioral level and partly in conjunction with neural measures. The samples used in the identified studies included individuals at increased risk of bipolar disorder, patients with current affective episodes, and patients with euthymic mood state.
In summary, the reviewed studies' results indicate impairments in explicit emotion regulation in individuals at risk for bipolar disorder, patients with manic and depressive episodes, and euthymic patients. These deficits manifest in subjective behavioral measures as well as in neural aberrations. Further, our review reveals a discrepancy between behavioral and neural findings regarding explicit emotion regulation in individuals at risk for bipolar disorders and euthymic patients. While these groups often do not differ significantly in behavioral measures from healthy and low-risk individuals, neural differences are mainly found in frontostriatal networks.
We conclude that these neural aberrations are a potentially sensitive measure of the probability of occurrence and recurrence of symptoms of bipolar disorders and that strengthening this frontostriatal route is a potentially protective measure for individuals at risk and patients who have bipolar disorders.
本研究旨在汇编和综合调查双相情感障碍患者及有患双相情感障碍风险个体的外显情绪调节的研究。外显情绪调节的重要性源于其在有风险个体中作为双相情感障碍标志物的潜在作用及其在双相情感障碍患者治疗中的重要作用。
为了全面汇编专门涉及双相情感障碍中外显情绪调节的研究，我们在四个数据库中进行了系统的文献检索。在我们纳入综述的15项研究中，情绪调节策略维持、分心和重新评估（自我聚焦和情境聚焦）部分在纯行为层面进行了研究，部分与神经测量相结合。已确定研究中使用的样本包括双相情感障碍风险增加的个体、当前有情感发作的患者以及心境正常的患者。
总之，综述研究结果表明，有双相情感障碍风险的个体、有躁狂和抑郁发作的患者以及心境正常的患者在外显情绪调节方面存在缺陷。这些缺陷在主观行为测量以及神经异常中均有体现。此外，我们的综述揭示了在有双相情感障碍风险的个体和心境正常的患者中，关于外显情绪调节的行为和神经研究结果之间存在差异。虽然这些群体在行为测量方面通常与健康和低风险个体没有显著差异，但神经差异主要出现在额纹状体网络中。
我们得出结论，这些神经异常是双相情感障碍症状发生和复发可能性的潜在敏感指标，加强这条额纹状体通路对有风险个体和患有双相情感障碍的患者可能是一种保护措施。
