Lu Xien, Kataoka Keiko, Kumagai Mariko, Nochi Yuta, Yamamoto Akiko, Ko Rie, Okada Annabelle A
Department of Ophthalmology, Kyorin University School of Medicine, 6-20-2 Shinkawa, Mitaka-shi, Tokyo, Japan.
Department of Ophthalmology, Juntendo University Faculty of Medicne, Tokyo, Japan.
Jpn J Ophthalmol. 2025 Jun 26. doi: 10.1007/s10384-025-01239-7.
To assess the effect of increased injection volume on intraocular pressure (IOP) following intravitreal injections of aflibercept 8 mg (70 µl) compared to conventional anti-vascular endothelial growth factor drugs.
Retrospective observational study METHODS: This retrospective observational study included eyes treated with 50 µl of either aflibercept 2 mg or faricimab 6 mg, followed by a switch to 70 µl of aflibercept 8 mg. IOP was measured before and 30 minutes after intravitreal injections. IOP changes in treated and fellow eyes were analyzed, with potential associations examined between IOP changes and clinical parameters.
A total of 88 eyes from 85 patients were switched to aflibercept 8 mg during the study period. Due to incomplete data, 17 eyes from 15 patients were excluded, leaving 71 eyes from 70 patients for the analysis. IOP significantly increased from 13.2 ± 2.9 mmHg to 19.1± 5.4 mmHg (P< 0.001) with 50 µl injections and from 13.3 ± 2.9 mmHg to 19.8 ± 4.8 mmHg (P<0.001) with 70 µl injections. The IOP increases were 6.0 ± 5.0 mmHg with 50 µl injections and 6.5 ± 4.3 mmHg with 70 µl injections, with no statistically significant difference (P = 0.20). An IOP exceeding 26 mmHg was observed in 6 eyes treated with 50 µl injections and 10 eyes with 70 µl injections, with no significant difference in IOP distribution between the volumes (P = 0.20).
There was no additional increase in IOP 30 minutes after intravitreal injections when switching from 50 µl to 70 µl volumes.
评估与传统抗血管内皮生长因子药物相比，玻璃体内注射8毫克阿柏西普（70微升）时增加注射体积对眼压（IOP）的影响。
回顾性观察研究
这项回顾性观察研究纳入了接受2毫克阿柏西普或6毫克法西单抗50微升注射治疗的眼睛，随后改用70微升8毫克阿柏西普。在玻璃体内注射前和注射后30分钟测量眼压。分析治疗眼和对侧眼的眼压变化，并检查眼压变化与临床参数之间的潜在关联。
在研究期间，共有85例患者的88只眼睛改用了8毫克阿柏西普。由于数据不完整，排除了15例患者的17只眼睛，剩余70例患者的71只眼睛用于分析。50微升注射时眼压从13.2±2.9毫米汞柱显著升高至19.1±5.4毫米汞柱（P<0.001），70微升注射时眼压从13.3±2.9毫米汞柱显著升高至19.8±4.8毫米汞柱（P<0.001）。50微升注射时眼压升高6.0±5.0毫米汞柱，70微升注射时眼压升高6.5±4.3毫米汞柱，无统计学显著差异（P = 0.20）。50微升注射治疗的6只眼睛和70微升注射治疗的10只眼睛观察到眼压超过26毫米汞柱，不同注射体积之间的眼压分布无显著差异（P = 0.20）。
从50微升改为70微升注射后，玻璃体内注射30分钟时眼压没有额外升高。
