Zoabi Narmin, Zelikovich Dorit, Kanani Fahim, Ram Edward, Issa Amina, Carter Dan
Gastroenterology Department, Sheba Medical Center, Ramat Gan, Israel.
The Faculty of Medicine, Ariel University, Ariel, Israel.
Am J Physiol Gastrointest Liver Physiol. 2025 Aug 1;329(2):G270-G275. doi: 10.1152/ajpgi.00100.2025. Epub 2025 Jun 26.
Defecatory dysfunction (DD) is a common cause of chronic constipation resulting from functional abnormalities or structural pelvic pathologies. Accurate diagnosis requires combining anorectal manometry (ARM), balloon expulsion test (BET), and defecography. This study evaluates the diagnostic utility of these modalities and explores uncertainties in their performance and interpretation. This retrospective study included 325 adult patients assessed for DD between 2020 and 2023. All patients went through ARM, BET in the left lateral position, and defecography. Statistical associations between test outcomes were analyzed to assess diagnostic concordance and significance. A strong correlation was observed between ARM and defecography, with 65% of patients with normal anal relaxation on ARM achieving normal rectal evacuation on defecography ( < 0.0001). Conversely, patients with paradoxical contraction during ARM demonstrated a higher likelihood of evacuation failure. BET demonstrated high specificity but limited sensitivity in association with relaxation on ARM and evacuation on defecography. BET failure did not demonstrate a significant association with the presence of pelvic floor pathologies. Combining ARM, BET, and defecography provides a comprehensive framework for diagnosing DD, addressing its functional and structural components. This integrated approach facilitates targeted interventions, ultimately improving clinical outcomes. This study demonstrates that anal relaxation on anorectal manometry significantly correlates with rectal evacuation on defecography, supporting its physiological relevance. Balloon expulsion in the left lateral position shows high specificity but low sensitivity for defecatory dysfunction. Notably, balloon expulsion test (BET) failure was not associated with anatomical abnormalities. An integrated diagnostic approach using anorectal manometry (ARM), BET, and defecography enhances accuracy in distinguishing functional from structural causes of pelvic floor dysfunction.
排便功能障碍(DD)是由功能异常或骨盆结构病变导致的慢性便秘的常见原因。准确诊断需要结合肛门直肠测压法(ARM)、气囊排出试验(BET)和排粪造影。本研究评估了这些检查方法的诊断效用,并探讨了其性能和解读中的不确定性。这项回顾性研究纳入了2020年至2023年间接受DD评估的325例成年患者。所有患者均接受了ARM、左侧卧位的BET和排粪造影。分析检查结果之间的统计关联,以评估诊断一致性和显著性。观察到ARM与排粪造影之间存在强相关性,ARM检查时肛门松弛正常的患者中,65%在排粪造影时直肠排空正常(<0.0001)。相反,ARM检查时出现矛盾收缩的患者排空失败的可能性更高。BET在与ARM检查时的松弛及排粪造影时的排空相关性方面显示出高特异性但有限的敏感性。BET失败与盆底病变的存在未显示出显著关联。结合ARM、BET和排粪造影为诊断DD提供了一个全面的框架,涵盖了其功能和结构组成部分。这种综合方法有助于进行有针对性的干预,最终改善临床结果。本研究表明,肛门直肠测压时的肛门松弛与排粪造影时的直肠排空显著相关,支持其生理相关性。左侧卧位的气囊排出试验对排便功能障碍显示出高特异性但低敏感性。值得注意的是,气囊排出试验(BET)失败与解剖学异常无关。使用肛门直肠测压法(ARM)、BET和排粪造影的综合诊断方法提高了区分盆底功能障碍功能性与结构性原因的准确性。