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膀胱癌治疗资金来源的生存情况:巴西圣保罗大型公共数据库分析

Survival According to Source of Treatment Funding in Bladder Cancer: Analysis of a Large Public Database From São Paulo, Brazil.

作者信息

Maluf Fernando C, de Oliveira Cintia S K S, Ziegelmann Patrícia K

机构信息

Hospital Israelita Albert Einstein, São Paulo, Brazil.

Hospital Beneficência Portuguesa de São Paulo, São Paulo, Brazil.

出版信息

JCO Glob Oncol. 2025 Jun;11:e2400648. doi: 10.1200/GO-24-00648. Epub 2025 Jun 26.

Abstract

PURPOSE

Previous studies have shown differences in patient profile and outcomes depending on the source of health care funding. Here, we evaluated the overall survival (OS) of patients with bladder cancer in public and in private systems in São Paulo, Brazil.

METHODS

We conducted a retrospective cohort study of patients with bladder cancer registered in the Registro Hospitalar de Câncer da Fundação Oncocentro de São Paulo, a large state-wide database. Eligibility required a diagnosis of non-muscle-invasive or invasive bladder cancer between 2013 and 2018. The main objective was to compare OS between private and public treatment-funding sources.

RESULTS

Of 21,090 patients with bladder cancer since database inception, 6,217 were eligible (82.4% with a public source of health care funding). Patients with a public source had more advanced TNM stages at diagnosis and were less likely to have noninvasive papillary transitional-cell carcinoma. Within a 5-year follow-up period, median OS was not reached in either group. Funding source was significantly associated with OS in favor of private source (hazard ratio [HR], 1.72 [95% CI, 1.51 to 1.96]; < .001), even after adjustment for age, TNM stage, and educational level (HR, 1.41 [95% CI, 1.21 to 1.65]; < .001). The 5-year OS rate was 68.5% (95% CI, 68.5% to 68.5%) and 53.71% (95% CI, 53.7% to 53.7%) for private and public groups, respectively.

CONCLUSION

Public source of funding was associated with a lower OS for bladder cancer. Much progress is required to ensure higher standards of health care focusing on patients treated at public sources.

摘要

目的

既往研究表明,根据医疗保健资金来源不同,患者情况和治疗结果存在差异。在此,我们评估了巴西圣保罗公立和私立医疗系统中膀胱癌患者的总生存期(OS)。

方法

我们对圣保罗肿瘤中心基金会医院癌症登记处登记的膀胱癌患者进行了一项回顾性队列研究,该登记处是一个大型的全州数据库。纳入标准为2013年至2018年间诊断为非肌层浸润性或浸润性膀胱癌。主要目的是比较私立和公立治疗资金来源患者的总生存期。

结果

自数据库建立以来的21090例膀胱癌患者中,6217例符合条件(82.4%有公共医疗保健资金来源)。公共资金来源的患者在诊断时TNM分期更高,且不太可能患有非浸润性乳头状移行细胞癌。在5年随访期内,两组均未达到中位总生存期。资金来源与总生存期显著相关,私立资金来源更具优势(风险比[HR],1.72[95%CI,1.51至1.96];P<.001),即使在调整年龄、TNM分期和教育水平后(HR,1.41[95%CI,1.21至1.65];P<.001)。私立和公立组的5年总生存率分别为68.5%(95%CI,68.5%至68.5%)和53.71%(95%CI,53.7%至53.7%)。

结论

公共资金来源与膀胱癌患者较低的总生存期相关。要确保以公立医疗系统治疗的患者为重点的更高医疗保健标准,仍需取得很大进展。

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