Ahmad Syed Ameen, Zawitoski Haley, Hiel Hakim, Balhi Yassine, Lauer Amanda, Kaufman Adam, Ward Bryan K
Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland.
West Virginia University School of Medicine, Morgantown, West Virginia.
Otol Neurotol. 2025 Jun 18. doi: 10.1097/MAO.0000000000004593.
To report a case of calcification discovered in the membranous labyrinth of a patient with a vestibular schwannoma after transtemporal labyrinthectomy.
Clinical capsule report.
Tertiary academic referral center.
An adult male with a 3-year history of left-sided hearing loss and balance issues was confirmed by MRI to have a cystic vestibular schwannoma.
Transtemporal labyrinthectomy.
Appearance of the membranous labyrinth on CT imaging and immunohistochemistry.
A patient presented with a 3-year history of left-sided hearing loss and balance issues. MRI revealed a heterogeneously enhancing mass in the left cerebellopontine angle, consistent with a cystic vestibular schwannoma. After a transtemporal labyrinthectomy, a gross examination revealed calcification within the membranous labyrinth. Retrospective review of imaging identified a preoperative ring of calcification, confirmed with visual inspection of the removed tissue via light microscope. Immunohistochemical analysis demonstrated a reduced number of nuclei in the hypertrophied crista compared with the unaffected crista.
Calcification in the membranous labyrinth may reflect underlying inner ear pathology. Further research is warranted to establish reliable methods for detecting this calcification to enhance our understanding of inner ear disorders.
报告1例经颞骨迷路切除术后在前庭神经鞘瘤患者膜迷路中发现钙化的病例。
临床简要报告。
三级学术转诊中心。
一名成年男性，有3年左侧听力损失和平衡问题病史，MRI确诊为囊性前庭神经鞘瘤。
经颞骨迷路切除术。
CT成像及免疫组织化学检查中膜迷路的表现。
一名有3年左侧听力损失和平衡问题病史的患者。MRI显示左侧小脑脑桥角有一个不均匀强化的肿块，符合囊性前庭神经鞘瘤。经颞骨迷路切除术后，大体检查发现膜迷路内有钙化。回顾性影像学检查发现术前有钙化环，通过光学显微镜对切除组织的目视检查得以证实。免疫组织化学分析显示，与未受影响的嵴相比，肥大嵴中的细胞核数量减少。
膜迷路中的钙化可能反映潜在的内耳病变。有必要进一步研究以建立检测这种钙化的可靠方法，以增进我们对内耳疾病的了解。
