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某些化学物质对黄曲霉菌丝体单位抗辐射性的修饰作用。

Modification of the radiation resistance of Aspergillus flavus mycelial units by some chemicals.

作者信息

Mohyuddin M, Skoropad W P

出版信息

Radiat Environ Biophys. 1977 Apr 27;14(1):39-45. doi: 10.1007/BF01331028.

DOI:10.1007/BF01331028
PMID:405704
Abstract

Survival curves for the mycleium of Aspergillus flavus Link var. columnaris Raper and Fennell were constructed after irradiation with gamma rays in the presence of NaCl, NaBr, NaI, KCl, KBr, KI, CaCl2, CaBr2, CaI2, Ca(NO3)2, NaNO2, NaNO3, KNO2, iodoacetic acid, iodoacetamide and vitamin K5. In addition iodized salt was also tested. All the chemicals tested exhibited initial toxicity at zero dose. However, most of the chemicals demonstrated a synergism when present during irradiation. Compounds containing iodine were invariably the strongest radiosensitizers. The iodine present as an admixture in salt also retained its radiosensitizing character. Sodium bromide and calcium bromide behaved in a different way. The initial toxicity was reduced along with an increase in radiation dose resulting in more survival.

摘要

在用γ射线辐照黄曲霉Link变种柱状变种Raper和Fennell的菌丝体时,分别添加了NaCl、NaBr、NaI、KCl、KBr、KI、CaCl₂、CaBr₂、CaI₂、Ca(NO₃)₂、NaNO₂、NaNO₃、KNO₂、碘乙酸、碘乙酰胺和维生素K₅,构建了其存活曲线。此外,还测试了加碘盐。所有测试的化学物质在零剂量时均表现出初始毒性。然而,大多数化学物质在辐照期间存在时表现出协同作用。含碘化合物始终是最强的放射增敏剂。盐中作为混合物存在的碘也保留了其放射增敏特性。溴化钠和溴化钙的表现有所不同。随着辐射剂量的增加,初始毒性降低,存活数量增加。

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本文引用的文献

1
RADIATION PROTECTION BY CALCIUM GLUCONATE AND RECOVERY OF X-IRRADIATED CONIDIA OF NEUROSPORA CRASSA.
Radiat Res. 1963 Oct;20:227-46.
2
Radiosensitivity of continuous cultures: experiments with diploid yeast.连续培养物的放射敏感性:二倍体酵母实验
Radiat Res. 1975 Aug;63(2):336-45.