Zerbinati Luigi, Caccia Federica, Baciga Federica, Belvedere Murri Martino, Esposito Pasquale, Caruso Rosangela, Nistor Ionut, Meijers Bjorn, Basile Carlo, Combe Christian, Grassi Luigi, Mantovani Alessandro, Battaglia Yuri
Institute of Psychiatry, Department of Biomedical and Specialty Surgical Sciences, University of Ferrara, Ferrara, Italy.
Department of Medicine, University of Verona, Verona, Italy.
Ren Fail. 2025 Dec;47(1):2521453. doi: 10.1080/0886022X.2025.2521453. Epub 2025 Jun 26.
Kidney failure is strongly associated with psychological disorders, including anxiety, depression, and suicidal ideation. However, the prevalence of suicide risk in patients undergoing dialysis has not been fully established.
We performed a systematic review and meta-analysis aimed at assessing the prevalence of suicide risk in adult patients on dialysis and any correlation with demographic and clinical parameters.
Twelve unique cross-sectional studies involving 1259 adult patients on dialysis were included. All patients were receiving hemodialysis treatment. In univariate meta-regression analysis, no significant effect of age, sex, and percentage of patients with diabetes mellitus on the prevalence of suicide risk was found. Overall, the prevalence of suicide risk was 20.6%. It varied widely, ranging from 4.0% to 57.3%, depending on the tools used (i.e. clinical interviews or self-report questionnaires). Among studies with more or less than 40% of patients on dialysis with anxiety and depression, the prevalence of suicide risk was very similar (21.2% vs 20.4%, respectively). The prevalence of suicide risk was more than double in lower-income than in higher-income countries (33.5% vs 15.3%, respectively).
The present systematic review and meta-analysis is a pioneering effort to identify the prevalence of suicide risk in patients on dialysis. It revealed a significant prevalence of suicide risk among hemodialysis patients, with a rate notably higher than that observed in the general population. This elevated risk is influenced by a complex combination of biological, psychological, and socio-economic factors.
肾衰竭与心理障碍密切相关，包括焦虑、抑郁和自杀念头。然而，透析患者自杀风险的患病率尚未完全明确。
我们进行了一项系统综述和荟萃分析，旨在评估成年透析患者自杀风险的患病率以及与人口统计学和临床参数的任何相关性。
纳入了12项独特的横断面研究，涉及1259名成年透析患者。所有患者均接受血液透析治疗。在单变量元回归分析中，未发现年龄、性别和糖尿病患者百分比对自杀风险患病率有显著影响。总体而言，自杀风险的患病率为20.6%。其差异很大，根据所使用的工具（即临床访谈或自我报告问卷），范围从4.0%到57.3%不等。在透析患者中焦虑和抑郁患者占比或多或少超过40%的研究中，自杀风险的患病率非常相似（分别为21.2%和20.4%）。低收入国家的自杀风险患病率比高收入国家高出一倍多（分别为33.5%和15.3%）。
本系统综述和荟萃分析是确定透析患者自杀风险患病率的开创性努力。它揭示了血液透析患者中自杀风险的显著患病率，该比率明显高于普通人群中观察到的比率。这种升高的风险受到生物学、心理和社会经济因素的复杂组合影响。
