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肾脏营养的注意事项:慢性肾病患者蛋白质限制和植物性饮食专家小组的实际考量

Dos and Don'ts in Kidney Nutrition: Practical Considerations of a Panel of Experts on Protein Restriction and Plant-Based Diets for Patients Living with Chronic Kidney Disease.

作者信息

Torreggiani Massimo, Avesani Carla Maria, Contzen Barbara, Cupisti Adamasco, Czaja-Stolc Sylwia, D'Alessandro Claudia, Garneata Liliana, Gutiérrez Abril, Lippi Françoise, Mocanu Carmen Antonia, Sabatino Alice, Piccoli Giorgina Barbara

机构信息

Néphrologie et Dialyse, Centre Hospitalier Le Mans, 72037 Le Mans, France.

Division of Renal Medicine, Baxter Novum, Department of Clinical Science Intervention and Technology, Karolinska Institutet, 14186 Stockholm, Sweden.

出版信息

Nutrients. 2025 Jun 14;17(12):2002. doi: 10.3390/nu17122002.

Abstract

Dietary management is a pillar of chronic kidney disease (CKD) treatment. While some rules are the same as dietary prescriptions for the general population and those suffering from other chronic diseases (energy intake, salt intake, avoidance of ultra-processed food and limited intake of animal fats), in non-dialysis-dependent patients living with CKD, the specific focus is on protein intake. Low-protein diets (LPDs) and supplemented very low protein diets (sVLPDs) have been successfully employed to decrease the symptoms of people living with non-dialysis-dependent CKD, delay the progression of the disease and retard the need for dialysis. Randomized clinical trials have yielded conflicting results on efficacy, resulting in conflicting guidelines. Concerns about the risk of malnutrition (specifically when the main source of proteins is plant-derived), electrolyte imbalances, and energy intake, and the idea that adherence is difficult, jeopardize the use and wide application of LPDs and sVLPDs. That dietary management focuses mainly on nutrients while dietary quality occupies second place is also an erroneous concept that requires discussion. In September 2023, a group of experts composed of nephrologists and dieticians gathered in Frankfurt, Germany, to try to reconcile the different guideline indications and address most of the common doubts of final dispatchers to increase the prescription of "renal diets" and improve people living with CKD's adherence to them.

摘要

饮食管理是慢性肾脏病(CKD)治疗的一大支柱。虽然有些规则与普通人群及其他慢性病患者的饮食处方相同(能量摄入、盐摄入、避免超加工食品以及限制动物脂肪摄入),但对于非透析依赖的CKD患者,重点在于蛋白质摄入。低蛋白饮食(LPDs)和补充型极低蛋白饮食(sVLPDs)已成功用于减轻非透析依赖CKD患者的症状、延缓疾病进展并推迟透析需求。随机临床试验在疗效方面得出了相互矛盾的结果,导致指南也相互冲突。对营养不良风险(特别是当蛋白质的主要来源是植物性时)、电解质失衡和能量摄入的担忧,以及认为依从性较差的观点,危及了LPDs和sVLPDs的使用及广泛应用。饮食管理主要关注营养素而将饮食质量置于次要地位,这也是一个需要讨论的错误观念。2023年9月,一组由肾病学家和营养师组成的专家齐聚德国法兰克福,试图协调不同的指南指征,并解决最终使用者的大多数常见疑问,以增加“肾脏饮食”的处方量,并提高CKD患者对其的依从性。

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