Liu Jiaying, Guan Yu, Yang Le, Fang Heng, Sun Hui, Sun Ye, Yan Guangli, Kong Ling, Wang Xijun
State Key Laboratory of Integration and Innovation of Classic Formula and Modern Chinese Medicine, National Chinmedomics Research Center, National TCM Key Laboratory of Serum Pharmacochemistry, Metabolomics Laboratory, Department of Pharmaceutical Analysis, Heilongjiang University of Chinese Medicine, Heping Road 24, Harbin 150040, China.
State Key Laboratory of Dampness Syndrome of Chinese Medicine, The Second Affiliated Hospital Guangzhou University of Chinese Medicine, Dade Road 111, Guangzhou 510000, China.
Pharmaceuticals (Basel). 2025 Jun 18;18(6):912. doi: 10.3390/ph18060912.
Ferulic acid (FA), a hydroxycinnamic acid derivative, is a key bioactive component in traditional medicinal plants including and . Accumulating evidence supports its therapeutic efficacy in inflammatory disorders, such as rheumatoid arthritis (RA) and ulcerative colitis (UC). FA exerts anti-inflammatory effects through (1) the regulation of inflammatory cytokine levels; (2) modulation of signaling pathways such as nuclear factor kappa B (NF-κB), mitogen-activated protein kinase (MAPK), and janus kinase/signal transducer and activator of transcription (JAK/STAT); (3) amelioration of oxidative stress; and (4) regulation of immune cell homeostasis. At the pharmacokinetic level, studies show that FA is rapidly absorbed but exhibits low bioavailability, mainly due to the influence of metabolic pathways and food matrix characteristics. This review systematically summarizes the literature on the anti-inflammatory effects of FA, covering molecular mechanisms, pharmacokinetic characteristics, and application scenarios. Preclinical studies show that FA has low toxicity and good safety, demonstrating potential for development as a novel anti-inflammatory drug. However, its clinical translation is hindered by bottlenecks such as low bioavailability and insufficient human clinical data. Future research should prioritize developing novel drug delivery systems and conducting large-scale clinical trials to facilitate its clinical translation.
阿魏酸（FA）是一种羟基肉桂酸衍生物，是包括[具体植物1]和[具体植物2]在内的传统药用植物中的关键生物活性成分。越来越多的证据支持其在炎症性疾病中的治疗功效，如类风湿性关节炎（RA）和溃疡性结肠炎（UC）。FA通过以下方式发挥抗炎作用：（1）调节炎症细胞因子水平；（2）调节信号通路，如核因子κB（NF-κB）、丝裂原活化蛋白激酶（MAPK）和janus激酶/信号转导和转录激活因子（JAK/STAT）；（3）减轻氧化应激；（4）调节免疫细胞稳态。在药代动力学水平上，研究表明FA吸收迅速，但生物利用度低，主要是由于代谢途径和食物基质特性的影响。本综述系统总结了关于FA抗炎作用的文献，涵盖分子机制、药代动力学特征和应用场景。临床前研究表明FA毒性低、安全性好，显示出作为新型抗炎药物的开发潜力。然而，其临床转化受到生物利用度低和人体临床数据不足等瓶颈的阻碍。未来的研究应优先开发新型药物递送系统并进行大规模临床试验，以促进其临床转化。
