Ruckebusch Y, Soldani G
J Vet Pharmacol Ther. 1985 Sep;8(3):263-9. doi: 10.1111/j.1365-2885.1985.tb00955.x.
Gallbladder motility was recorded as tonic and small amplitude (rhythmic) contractions in conscious sheep fitted with miniaturized strain-gauge force transducers located in the corpus and fundus. Nichrome wire electrodes were chronically implanted in the gastroduodenal area. Both tonic and superimposed rhythmic gallbladder contractions were increased during feeding. They decreased during the periodic phases of antroduodenal quiescence. The excitatory effects on gallbladder and antroduodenal motility were mimicked by pilocarpine and blocked by atropine. Cholecystokinin (CCK-OP) and caerulein elicited motor responses of the gallbladder in a dose-related manner without antroduodenal stimulation. In contrast, pentagastrin induced gallbladder motor responses with concomitant stimulation of the antroduodenal area. The results suggest that feeding may act to trigger gallbladder motor activity through a mechanism related to the increased antroduodenal activity. Direct effects of CCK-OP and caerulein confirm that gallbladder motor function is also mediated through specific receptor sites.
在装有位于胆囊体部和底部的小型应变片式力传感器的清醒绵羊中，胆囊运动被记录为张力性和小幅度（节律性）收缩。镍铬丝电极被长期植入胃十二指肠区域。进食期间，张力性和叠加的节律性胆囊收缩均增加。在胃十二指肠静止的周期性阶段，它们会减少。毛果芸香碱可模拟对胆囊和胃十二指肠运动的兴奋作用，而阿托品可阻断这种作用。胆囊收缩素（CCK-OP）和蛙皮素以剂量相关的方式引发胆囊的运动反应，而无需胃十二指肠刺激。相比之下，五肽胃泌素在刺激胃十二指肠区域的同时诱导胆囊运动反应。结果表明，进食可能通过与胃十二指肠活动增加相关的机制来触发胆囊运动活动。CCK-OP和蛙皮素的直接作用证实，胆囊运动功能也通过特定的受体位点介导。
