Katzberg R W, Morris T W, DiMarco P L, Merguerian P A, Ventura J A, Linke C A, Fischer H W
J Urol. 1985 Nov;134(5):1007-10. doi: 10.1016/s0022-5347(17)47577-x.
In order to assess the glomerular filtration responses to acute ureteral obstruction in the dog we employed an established method that does not require timed urine collections. Our results show a 57 per cent increase in renal blood flow (baseline: 203.8 +/- 50.9 vs. 319 +/- 69.4 ml./min. at 105 minutes; no. = 7) that was associated with a monophasic decrease in filtration fraction to -70 per cent at 120 minutes (0.26 +/- 0.025 vs. 0.08 +/- 0.007) and an increase in ureteral pressure to 63.1 +/- 6.1 mm. Hg at 120 minutes. A biphasic GFR response was noted with an initial small increase (baseline: 32.5 +/- 7.5 vs. 36.3 +/- 11.0 ml./min. at 2 minutes) followed by a continual decline to -55 per cent at 120 minutes (to 14.5 +/- 2.6 ml./min.). This investigation has confirmed the results of micropuncture studies showing maintenance of GFR early after complete ureteral ligation.
为了评估犬急性输尿管梗阻时的肾小球滤过反应，我们采用了一种既定方法，该方法无需定时收集尿液。我们的结果显示肾血流量增加了57%（基线：203.8±50.9 vs. 105分钟时为319±69.4毫升/分钟；n = 7），这与滤过分数在120分钟时单相下降至-70%（0.26±0.025 vs. 0.08±0.007）以及输尿管压力在120分钟时升高至63.1±6.1毫米汞柱有关。观察到肾小球滤过率（GFR）呈双相反应，最初有小幅增加（基线：2分钟时为32.5±7.5 vs. 36.3±11.0毫升/分钟），随后在120分钟时持续下降至-55%（降至14.5±2.6毫升/分钟）。本研究证实了微穿刺研究的结果，即完全输尿管结扎后早期肾小球滤过率得以维持。
