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人肺炎病毒的疫苗研发

Vaccine Development for Human Pneumoviruses.

作者信息

Mboup Elhadji Birane, Hamelin Marie-Ève, Dubois Julia, Rosa-Calatrava Manuel, Boivin Guy

机构信息

Infectious and Immune Diseases Research Program, CHU de Québec-Université Laval Research Center, Québec, QC G1V 4G2, Canada.

International Research Laboratory RESPIVIR France-Canada, Centre de Recherche en Infectiologie, Faculté de Médecine RTH Laennec, 69008 Lyon, France, Université Claude Bernard Lyon 1, Lyon, France, CHU de Québec-Université Laval Research Center, Québec, QC G1V 4G2, Canada.

出版信息

Vaccines (Basel). 2025 May 26;13(6):569. doi: 10.3390/vaccines13060569.


DOI:10.3390/vaccines13060569
PMID:40573900
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12197412/
Abstract

BACKGROUND: Pneumoviruses are etiologic agents of respiratory tract infections and a major cause of morbidity and mortality worldwide, particularly affecting young children, the elderly, and individuals with underlying clinical conditions. These viruses are associated with a significant burden, particularly in low- and middle-income countries, where reported deaths attributable to respiratory syncytial virus (RSV) and human metapneumovirus (HMPV) in young children are important. Recent developments have been noted in the prevention of pneumoviral infections. METHOD: In this review, we analyzed clinical trials of the approved RSV vaccines, as well as the recent prominent platform technologies used in RSV vaccine research. In addition, we discussed combination vaccines targeting RSV, HMPV, and Human Parainfluenza Virus Type 3 (HPIV3) that have entered clinical trials. RESULTS: Recent advancements include the approval of three RSV vaccine candidates: AREXVY(GSK), ABRYSVO(Pfizer), and mRESVIA(Moderna). These vaccines are primarily intended for older adults, with ABRYSVO also capable of providing passive immunization to infants via maternal administration. The review highlights RSV vaccine platform technologies and combination vaccines currently being evaluated in clinical settings. CONCLUSIONS: While significant progress has been made in RSV vaccine development, especially with three approved candidates, the development of vaccines for HMPV remains an unmet medical need. Ongoing research in combination vaccines holds promise for broader protection against multiple respiratory viruses in the future.

摘要

背景:肺病毒是呼吸道感染的病原体,是全球发病和死亡的主要原因,尤其影响幼儿、老年人以及有基础疾病的个体。这些病毒造成了巨大负担,特别是在低收入和中等收入国家,幼儿中因呼吸道合胞病毒(RSV)和人偏肺病毒(HMPV)导致的报告死亡情况较为严重。在预防肺病毒感染方面已有一些新进展。 方法:在本综述中,我们分析了已获批的RSV疫苗的临床试验,以及RSV疫苗研究中近期突出的平台技术。此外,我们还讨论了已进入临床试验的针对RSV、HMPV和3型人副流感病毒(HPIV3)的联合疫苗。 结果:近期进展包括三种RSV候选疫苗获批:AREXVY(葛兰素史克公司)、ABRYSVO(辉瑞公司)和mRESVIA(莫德纳公司)。这些疫苗主要针对老年人,ABRYSVO还能够通过母体给药为婴儿提供被动免疫。本综述重点介绍了目前正在临床环境中评估的RSV疫苗平台技术和联合疫苗。 结论:虽然RSV疫苗研发取得了重大进展,特别是有三种获批的候选疫苗,但HMPV疫苗的研发仍然是未满足的医疗需求。联合疫苗的持续研究有望在未来提供更广泛的针对多种呼吸道病毒的保护。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6dc6/12197412/dd9d6584540e/vaccines-13-00569-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6dc6/12197412/f3ad4ca8fbe2/vaccines-13-00569-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6dc6/12197412/dd9d6584540e/vaccines-13-00569-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6dc6/12197412/f3ad4ca8fbe2/vaccines-13-00569-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6dc6/12197412/dd9d6584540e/vaccines-13-00569-g002.jpg

相似文献

[1]
Vaccine Development for Human Pneumoviruses.

Vaccines (Basel). 2025-5-26

[2]
Immunoglobulin treatment for hospitalised infants and young children with respiratory syncytial virus infection.

Cochrane Database Syst Rev. 2023-10-23

[3]
Respiratory syncytial virus (RSV) infections in adults: Current trends and recommendations for prevention - a global challenge from a local perspective.

Hum Vaccin Immunother. 2025-12

[4]
Host immune response to respiratory syncytial virus infection and its contribution to protection and susceptibility in adults: a systematic literature review.

Expert Rev Clin Immunol. 2025-6

[5]
Palivizumab for preventing severe respiratory syncytial virus (RSV) infection in children.

Cochrane Database Syst Rev. 2021-11-16

[6]
Palivizumab for immunoprophylaxis of respiratory syncytial virus (RSV) bronchiolitis in high-risk infants and young children: a systematic review and additional economic modelling of subgroup analyses.

Health Technol Assess. 2011-1

[7]
Maternal RSVpreF Vaccine: A Novel Agent for Respiratory Syncytial Virus Prevention in Infants.

Ann Pharmacother. 2025-8

[8]
Vaccines for preventing influenza in the elderly.

Cochrane Database Syst Rev. 2018-2-1

[9]
Physical interventions to interrupt or reduce the spread of respiratory viruses.

Cochrane Database Syst Rev. 2023-1-30

[10]
Vaccines for preventing influenza in healthy children.

Cochrane Database Syst Rev. 2018-2-1

本文引用的文献

[1]
Annual Clinical and Economic Burden of Medically Attended Lower Respiratory Tract Illnesses Due to Respiratory Syncytial Virus Among US Infants Aged <12 Months.

J Infect Dis. 2025-6-2

[2]
A multivalent RSV vaccine based on the modified vaccinia Ankara vector shows moderate protection against disease caused by RSV in older adults in a phase 3 clinical study.

Vaccine. 2024-12-2

[3]
Changes in the epidemiological patterns of respiratory syncytial virus and human metapneumovirus infection among pediatric patients and their correlation with severe cases: a long-term retrospective study.

Front Cell Infect Microbiol. 2024

[4]
Safety and Immunogenicity of Respiratory Syncytial Virus Prefusion F Protein Vaccine when Co-administered with Adjuvanted Seasonal Quadrivalent Influenza Vaccine in Older Adults: A Phase 3 Randomized Trial.

Clin Infect Dis. 2024-10-15

[5]
Immunogenicity and Safety Following 1 Dose of AS01E-Adjuvanted Respiratory Syncytial Virus Prefusion F Protein Vaccine in Older Adults: A Phase 3 Trial.

J Infect Dis. 2024-7-25

[6]
Randomized, Open-Label Phase 3 Study Evaluating Immunogenicity, Safety, and Reactogenicity of RSVPreF3 OA Coadministered with FLU-QIV-HD in Adults Aged ≥ 65.

Infect Dis Ther. 2024-8

[7]
Differences Between RSV A and RSV B Subgroups and Implications for Pharmaceutical Preventive Measures.

Infect Dis Ther. 2024-8

[8]
Mucosal bivalent live attenuated vaccine protects against human metapneumovirus and respiratory syncytial virus in mice.

NPJ Vaccines. 2024-6-19

[9]
Seasonal and Genetic Characteristics of Human Metapneumovirus Circulating - Henan Province, China, 2017-2023.

China CDC Wkly. 2024-5-17

[10]
Long-term efficacy and immunogenicity of Ad26.RSV.preF-RSV preF protein vaccine (CYPRESS): a randomised, double-blind, placebo-controlled, phase 2b study.

Lancet Infect Dis. 2024-9

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