Picciòla G, Carissimi M, Ravenna F, Gentili P, Carenini G
Arzneimittelforschung. 1979;29(5):729-38.
The effect of variation of the cycloaliphatic residue position on pharmacological activity was studied in two series of cyclohexylphenoxy derivatives (A and B). (Formula: See text) The ortho derivatives generally exhibit remarkably strong activity; (A) has an imipramine-like pharmacological profile; (B) with Y = H is more active than naphazoline and xylomethazoline as vasoconstrictor. The meta and para substituted derivatives and all (B) derivatives with R = CH3 exhibited no definite or interesting pharmacological activities.
在两个系列的环己基苯氧基衍生物（A和B）中研究了脂环族残基位置变化对药理活性的影响。（分子式：见原文）邻位衍生物通常表现出非常强的活性；（A）具有类似丙咪嗪的药理特性；（Y = H的）（B）作为血管收缩剂比萘甲唑啉和赛洛唑啉更具活性。间位和对位取代的衍生物以及所有R = CH₃的（B）衍生物均未表现出明确或有趣的药理活性。
