Kuroda H, Kohrogi T, Uchida N, Imai I, Terada N, Matsumoto K, Kitamura Y
J Urol. 1985 Dec;134(6):1268-70. doi: 10.1016/s0022-5347(17)47709-3.
Daily subcutaneous injections of pharmacological doses of 17 beta-estradiol (E2, 0.4 micrograms./gm. body weight) resulted in significant urinary retention in the bladder of castrated mice. Although the urinary retention developed in both male and female mice, the increase in urethral resistance to urinary flow and the dilatation of posterior urethra were observed only in castrated male mice receiving E2. Histological changes common to male and female mice were cornification and stratification of urethral epithelium and fibrosis of connective tissues surrounding the urethra, suggesting that these changes may cause the urinary retention. Although the exact mechanism has not been defined, the urinary retention produced by the present method may be useful as a model of human disease.
每天皮下注射药理剂量的17β-雌二醇（E2，0.4微克/克体重）会导致去势小鼠膀胱出现明显的尿潴留。虽然雄性和雌性小鼠都会出现尿潴留，但仅在接受E2的去势雄性小鼠中观察到尿道对尿流的阻力增加以及后尿道扩张。雄性和雌性小鼠共有的组织学变化是尿道上皮的角质化和分层以及尿道周围结缔组织的纤维化，这表明这些变化可能导致尿潴留。虽然确切机制尚未明确，但通过本方法产生的尿潴留可能作为人类疾病的模型。
