Deng Zehui, Lin Fei, Zhou Ling, Wang Shaojuan, Li Jie, He Longxi
Department of Pharmacy, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Department of Pharmacy, the First Affiliated Hospital of Chengdu Medical College, Chengdu, Sichuan, China.
Noise Health. 2025;27(126):203-209. doi: 10.4103/nah.nah_187_24. Epub 2025 Jun 26.
With the rapid development of industrialisation, noise exposure is becoming increasingly prevalent. The detrimental effects of noise-induced hearing loss (NIHL) have become clinically relevant. Therefore, effective drug therapeutic strategies for NIHL are urgently needed. This article reviewed the pathophysiology and potential molecular mechanisms of NIHL and classified and summarised the drug therapeutic strategies. Drug therapeutic strategies of NIHL can be further studied in agents such as corticosteroids, antioxidants, neurotrophic factors, herbal medicine, magnesium and statins. Given the current research progress, ongoing positive test results and pilot studies may lead to new pharmacological regimens to alleviate NIHL.
随着工业化的迅速发展，噪声暴露日益普遍。噪声性听力损失（NIHL）的有害影响已具有临床相关性。因此，迫切需要针对NIHL的有效药物治疗策略。本文综述了NIHL的病理生理学和潜在分子机制，并对药物治疗策略进行了分类和总结。NIHL的药物治疗策略可在皮质类固醇、抗氧化剂、神经营养因子、草药、镁和他汀类药物等制剂中进一步研究。鉴于目前的研究进展，正在进行的阳性试验结果和初步研究可能会带来减轻NIHL的新药物治疗方案。
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