Chandimali Nisansala, Hong Seong-Min, Bae Jaehoon, Park Eun Hyun, Lim Hyung-Jin, Won Yeong-Seon, Kim Eun Kyung, Park Sang-Ik, Kim Yeon-Yong, Bak Seon Gyeong, Lee Seung-Jae
Functional Biomaterial Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Jeongeup, 56212, Korea.
Applied Biological Engineering, KRIBB School of Biotechnology, University of Science and Technology, Daejeon, 34113, Korea.
Curr Pharm Des. 2025 Jun 25. doi: 10.2174/0113816128368673250611114044.
Atopic dermatitis (AD) is a common chronic inflammatory skin disorder affecting both children and adults, characterized by intense itching, erythema, and xerosis. The pathogenesis of AD is multifactorial, involving genetic predisposition, immune dysregulation, skin barrier dysfunction, and environmental factors. A growing body of evidence suggests that oxidative stress plays a critical role in AD, contributing to chronic inflammation, immune cell activation, and skin barrier disruption. Oxidative stress arises from an imbalance between Reactive Oxygen Species (ROS) production and antioxidant defenses, leading to cellular damage and the exacerbation of AD symptoms. Recent research has highlighted the potential of plant-derived bioactive compounds, particularly those with antioxidant properties, to mitigate oxidative stress and provide therapeutic benefits in AD. These compounds, including quercetin, resveratrol, curcumin, silymarin, baicalin, luteolin, and epigallocatechin gallate, not only neutralize ROS but also exhibit anti-inflammatory, immunomodulatory, and skin barrier-restoring effects. Natural antioxidants from plants offer a safer alternative to conventional treatments, which may have long-term side effects. This review provides a comprehensive overview of the mechanisms by which oxidative stress contributes to AD and examines the potential of plant-derived antioxidants in alleviating AD symptoms. The growing interest in these compounds underscores the need for further research to harness their full therapeutic potential in AD management.
特应性皮炎（AD）是一种常见的慢性炎症性皮肤病，影响儿童和成人，其特征为剧烈瘙痒、红斑和皮肤干燥。AD的发病机制是多因素的，涉及遗传易感性、免疫失调、皮肤屏障功能障碍和环境因素。越来越多的证据表明，氧化应激在AD中起关键作用，导致慢性炎症、免疫细胞活化和皮肤屏障破坏。氧化应激源于活性氧（ROS）产生与抗氧化防御之间的失衡，导致细胞损伤和AD症状加重。最近的研究强调了植物源生物活性化合物，特别是具有抗氧化特性的化合物，减轻氧化应激并在AD中提供治疗益处的潜力。这些化合物，包括槲皮素、白藜芦醇、姜黄素、水飞蓟宾、黄芩苷、木犀草素和表没食子儿茶素没食子酸酯，不仅能中和ROS，还具有抗炎、免疫调节和恢复皮肤屏障的作用。植物中的天然抗氧化剂为可能有长期副作用的传统治疗提供了更安全的替代方案。本文综述了氧化应激导致AD的机制，并探讨了植物源抗氧化剂缓解AD症状的潜力。对这些化合物的兴趣日益增加，凸显了进一步研究以充分发挥其在AD治疗中的全部潜力的必要性。
