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微生物组、代谢组和转录组分析揭示的复方阿胶浆造血作用：一种多组学策略

Hematopoietic effects of Fufang E'jiao Jiang revealed by microbiome, metabolome and transcriptome analyses: a multi-omics strategy.

作者信息

Mo Yueting, He Xiyuan, Shi Peixin, Ning Yifei, Zhou Mingmei, Cui Hao, Zhang Ting

机构信息

Institute for Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai, China.

Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, China.

出版信息

Front Immunol. 2025 Jun 12;16:1561477. doi: 10.3389/fimmu.2025.1561477. eCollection 2025.

DOI:10.3389/fimmu.2025.1561477
PMID:40574855
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12197926/
Abstract

INTRODUCTION: Fufang E'jiao Jiang has been extensively utilized to replenish qi and nourish blood as the homology of medicine and food. METHODS: We analyzed the effects of FEJ on cyclophosphamide and acetylphenylhydrazine-induced anemia mice through gut microbiome analysis, fecal metabolomics, and transcriptome sequencing. RESULTS: FEJ markedly alleviated the anemia symptoms in the mice. FEJ markedly alleviated the anemia symptoms caused by cyclophosphamide and acetylphenylhydrazine induction. FEJ improved the gut microbiome imbalance by inhibiting the proliferation of harmful bacteria and . Fecal metabolomic data showed that FEJ regulated metabolic disorders in anemia mice and was probably associated with L-leucine, L-proline, glycine, phenylalanine, propanoic acid and butanoic acid. Transcriptome analysis indicated the amelioration of anemia was predominantly associated with the hematopoietic cell lineage, osteoclast formation and B cell receptor signaling pathway. According to Spearman's correlation analysis, there was a strong link between gut microbiota and hematopoietic index, metabolites and genes. DISCUSSION: Our study supports the application of FEJ in anemia treatment.

摘要

引言：复方阿胶浆作为药食同源的产品，已被广泛用于补气养血。 方法：我们通过肠道微生物组分析、粪便代谢组学和转录组测序，分析了复方阿胶浆对环磷酰胺和乙酰苯肼诱导的贫血小鼠的影响。 结果：复方阿胶浆显著减轻了小鼠的贫血症状。复方阿胶浆显著减轻了环磷酰胺和乙酰苯肼诱导引起的贫血症状。复方阿胶浆通过抑制有害细菌的增殖改善了肠道微生物组失衡。粪便代谢组学数据表明，复方阿胶浆调节了贫血小鼠的代谢紊乱，可能与L-亮氨酸、L-脯氨酸、甘氨酸、苯丙氨酸、丙酸和丁酸有关。转录组分析表明，贫血的改善主要与造血细胞谱系、破骨细胞形成和B细胞受体信号通路有关。根据Spearman相关性分析，肠道微生物群与造血指标、代谢物和基因之间存在密切联系。 讨论：我们的研究支持复方阿胶浆在贫血治疗中的应用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae9e/12197926/47b9dd0011a7/fimmu-16-1561477-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae9e/12197926/179abe47782b/fimmu-16-1561477-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae9e/12197926/ca1777b0860f/fimmu-16-1561477-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae9e/12197926/2b08bd1feddc/fimmu-16-1561477-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae9e/12197926/ae0f7e977494/fimmu-16-1561477-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae9e/12197926/29063d81177c/fimmu-16-1561477-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae9e/12197926/c3aece1001be/fimmu-16-1561477-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae9e/12197926/47b9dd0011a7/fimmu-16-1561477-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae9e/12197926/179abe47782b/fimmu-16-1561477-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae9e/12197926/ca1777b0860f/fimmu-16-1561477-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae9e/12197926/2b08bd1feddc/fimmu-16-1561477-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae9e/12197926/ae0f7e977494/fimmu-16-1561477-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae9e/12197926/29063d81177c/fimmu-16-1561477-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae9e/12197926/c3aece1001be/fimmu-16-1561477-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae9e/12197926/47b9dd0011a7/fimmu-16-1561477-g007.jpg

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本文引用的文献

[1]
Preliminary screening of biomarkers and drug candidates in a mouse model of β-thalassemia based on quasi-targeted metabolomics.

Front Physiol. 2024-8-23

[2]
Angelica sinensis polysaccharides promote extramedullary stress erythropoiesis via ameliorating splenic glycolysis and EPO/STAT5 signaling-regulated macrophages.

J Mol Histol. 2024-10

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Review of Codonopsis Radix biological activities: A plant of traditional Chinese tonic.

J Ethnopharmacol. 2024-10-5

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Front Pharmacol. 2024-3-8

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Disrupted Tuzzerella abundance and impaired L-glutamine levels induce Treg accumulation in ovarian endometriosis: a comprehensive multi-omics analysis.

Metabolomics. 2024-2-29

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Xiao Cheng Qi Decoction, an Ancient Chinese Herbal Mixture, Relieves Loperamide-Induced Slow-Transit Constipation in Mice: An Action Mediated by Gut Microbiota.

Pharmaceuticals (Basel). 2024-1-24

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B cell subsets contribute to myocardial protection by inducing neutrophil apoptosis after ischemia and reperfusion.

JCI Insight. 2024-2-22

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Butyrate Prevents the Pathogenic Anemia-Inflammation Circuit by Facilitating Macrophage Iron Export.

Adv Sci (Weinh). 2024-3

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