Furuya K, Wada N, Kawaguchi N, Amino K
Gan No Rinsho. 1985 Jul;31(9 Suppl):1063-72.
The result of the group study on adjuvant chemotherapy with HD-MTX, ADR and CPM for 25 cases of osteosarcomas is as follows: Overall survival at three and a half years is 58.4% and the disease-free survival is 40%. In our clinics, 66 cases of osteosarcomas were treated by the radical surgery from 1955. Overall survival of these cases at five years was 49%. Overall survival between 1955 and 1974 was 43% and that from 1975, the year when ADR was introduced, to date was 55%. The data of the group study of soft tissue sarcoma sponsored by Ministry of Health and Welfare show that in 318 cases of soft tissue sarcomas of extremities, the recurrence rate during the period between 1962 and 1976 is 52%, metastasis rate 69%, and overall survival at 5 years 42%. From 1972 to 1983, in 414 cases treated by the orthopaedic clinics of the same group the recurrence rate become as low as 23% metastasis rate 45% and overall survival at 5 years 56%. In our clinics, 89 patients with soft tissue sarcomas were treated by the curative wide resection and the recurrence rate is 12%, metastasis rate 25%, and overall survival at 5 years 78%. In this series, in 80% of cases limb salvage is succeeded.
对25例骨肉瘤患者采用大剂量甲氨蝶呤、阿霉素和环磷酰胺进行辅助化疗的分组研究结果如下：三年半的总生存率为58.4%，无病生存率为40%。在我们的诊所，自1955年以来有66例骨肉瘤患者接受了根治性手术。这些患者的五年总生存率为49%。1955年至1974年期间的总生存率为43%，自1975年（引入阿霉素的年份）至今的总生存率为55%。厚生省赞助的软组织肉瘤分组研究数据显示，在318例四肢软组织肉瘤患者中，1962年至1976年期间的复发率为52%，转移率为69%，五年总生存率为42%。1972年至1983年，同一组骨科诊所治疗的414例患者中，复发率低至23%，转移率为45%，五年总生存率为56%。在我们的诊所，89例软组织肉瘤患者接受了根治性广泛切除，复发率为12%，转移率为25%，五年总生存率为78%。在该系列中，8个案例成功进行了保肢手术。
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