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From Immunity to Oncology: Itaconic Acid as a Driver in HBV-Induced HCC.

作者信息

Mahmoudvand Shahab, Sheikhrobat Sheida Behzadi, Shokri Somayeh, Baghi Hossein Bannazadeh

机构信息

Infectious Disease Research Center, Hamadan University of Medical Sciences, Hamadan, Iran.

Department of Virology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.

出版信息

J Cell Mol Med. 2025 Jun;29(12):e70612. doi: 10.1111/jcmm.70612.

DOI:10.1111/jcmm.70612
PMID:40576207
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12203388/
Abstract
摘要

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J Cell Mol Med. 2025 Jun;29(12):e70612. doi: 10.1111/jcmm.70612.
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本文引用的文献

1
Enhancing HBV-specific T cell responses through a combination of epigenetic modulation and immune checkpoint inhibition.通过表观遗传调控和免疫检查点抑制相结合来增强乙肝病毒特异性T细胞反应。
Hepatology. 2025 Sep 1;82(3):739-754. doi: 10.1097/HEP.0000000000001202. Epub 2024 Dec 19.
2
A liver immune rheostat regulates CD8 T cell immunity in chronic HBV infection.肝脏免疫调节装置调控慢性乙型肝炎病毒感染中的 CD8 T 细胞免疫。
Nature. 2024 Jul;631(8022):867-875. doi: 10.1038/s41586-024-07630-7. Epub 2024 Jul 10.
3
Control of immune cell signaling by the immuno-metabolite itaconate.免疫代谢产物衣康酸调控免疫细胞信号转导。
Front Immunol. 2024 Feb 28;15:1352165. doi: 10.3389/fimmu.2024.1352165. eCollection 2024.
4
Itaconate promotes hepatocellular carcinoma progression by epigenetic induction of CD8 T-cell exhaustion.衣康酸盐通过表观遗传诱导 CD8 T 细胞耗竭促进肝细胞癌进展。
Nat Commun. 2023 Dec 9;14(1):8154. doi: 10.1038/s41467-023-43988-4.
5
The yin and yang of itaconate metabolism and its impact on the tumor microenvironment.异丁烯酸代谢的阴阳两面及其对肿瘤微环境的影响。
Curr Opin Biotechnol. 2023 Dec;84:102996. doi: 10.1016/j.copbio.2023.102996. Epub 2023 Oct 6.
6
Itaconate ameliorates autoimmunity by modulating T cell imbalance via metabolic and epigenetic reprogramming.衣康酸盐通过代谢和表观遗传重编程调节 T 细胞失衡来改善自身免疫。
Nat Commun. 2023 Feb 27;14(1):984. doi: 10.1038/s41467-023-36594-x.
7
CD8(+) T cells mediate viral clearance and disease pathogenesis during acute hepatitis B virus infection.CD8(+) T细胞在急性乙型肝炎病毒感染期间介导病毒清除和疾病发病机制。
J Virol. 2003 Jan;77(1):68-76. doi: 10.1128/jvi.77.1.68-76.2003.