Shinkai T, Saijo N, Yoshioka S, Suemasu K, Hasegawa H, Miyazawa N, Kamiya T, Kanzawa F, Nakajima T, Shimosato Y
Jpn J Clin Oncol. 1985 Sep;15(3):567-75.
A 59-year-old woman was admitted to the hospital because of recurrence of thymoma with appearance of myasthenia gravis 18 years after excision of an invasive thymoma. Recurrence was observed in the anterior mediastinum, right pleura, pericardium and left supraclavicular lymph node. Hashimoto's thyroiditis, vitiligo vulgaris and leukopenia were also seen. After creation of a pericardial window for pericardial effusion, she received vincristine, then carbazilquinone intravenously as single chemotherapeutic agents based on the chemosensitivity by clonogenic assay of the supraclavicular tumor, but response was not achieved. At one and a half years after radiotherapy to the mediastinum, she is now doing well without symptoms and is receiving a fairly low dose of anticholinesterase medication.
一名59岁女性因侵袭性胸腺瘤切除术后18年胸腺瘤复发并出现重症肌无力而入院。在前纵隔、右胸膜、心包和左锁骨上淋巴结发现复发。还发现有桥本甲状腺炎、寻常型白癜风和白细胞减少症。因心包积液做了心包开窗术后，根据锁骨上肿瘤克隆形成试验的化疗敏感性，她先后接受了长春新碱、卡巴醌静脉注射作为单一化疗药物，但未取得疗效。纵隔放疗后一年半，她目前情况良好，没有症状，正在接受低剂量抗胆碱酯酶药物治疗。
