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他司美琼对创伤性脑损伤大鼠模型肾损伤的保护作用：一项组织病理学和免疫组织化学研究

Protective effects of tasimelteon on kidney injury in a traumatic brain injury rat model: a histopathological and immunohistochemical study.

作者信息

Milletsever Adem, Asci Halil, Taner Rumeysa, Ozmen Ozlem

机构信息

Department of Pathology, Faculty of Veterinary Medicine, Burdur Mehmet Akif Ersoy University, Burdur, Türkiye.

Department of Pharmacology, Faculty of Medicine, Suleyman Demirel University, Isparta, Türkiye.

出版信息

Eur J Trauma Emerg Surg. 2025 Jun 27;51(1):241. doi: 10.1007/s00068-025-02915-6.

DOI:10.1007/s00068-025-02915-6
PMID:40576729
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12205017/
Abstract

PURPOSE

Traumatic brain injury (TBI) is a condition characterized by structural and functional damage to the brain following trauma and is a significant cause of mortality. Acute kidney injury (AKI) has been reported in patients with TBI and is a commonly encountered complication. This study examines the effect of tasimelteon (Tasi) application on kidney tissue in TBI rats by histopathological and immunohistochemical staining.

METHODS

Forty male Wistar Albino rats weighing 300–350 g were randomly divided into four groups: Control group, Trauma group (Trau), Trau-Tasi-1 group (trauma-1 mg/kg Tasi intraperitoneally), and Trau-Tasi-10 group (trauma-10 mg/kg Tasi intraperitoneally). At the end of the experimental phase, after euthanasia, kidney tissue was collected for histopathological and immunohistochemical analyses.

RESULTS

The results of histopathological and immunohistochemical staining demonstrate that brain trauma may induce kidney injury, while Tasi possesses the potential to ameliorate kidney lesions associated with TBI. It has been found that Trau-Tasi-10 is more effective in treatment compared to Trau-Tasi-1.

CONCLUSION

We observed Tasi’s kidney injury ameliorating activity in TBI rats through histopathological and immunohistochemical staining findings.

SUPPLEMENTARY INFORMATION

The online version contains supplementary material available at 10.1007/s00068-025-02915-6.

摘要

目的

创伤性脑损伤（TBI）是一种因创伤导致脑结构和功能受损的疾病，是死亡的重要原因。已有报道称TBI患者会出现急性肾损伤（AKI），这是一种常见的并发症。本研究通过组织病理学和免疫组织化学染色，研究他司美琼（Tasi）应用对TBI大鼠肾组织的影响。

方法

将40只体重300 - 350 g的雄性Wistar白化大鼠随机分为四组：对照组、创伤组（Trau）、Trau - Tasi - 1组（创伤后腹腔注射1 mg/kg Tasi）和Trau - Tasi - 10组（创伤后腹腔注射10 mg/kg Tasi）。实验阶段结束后，安乐死大鼠后，收集肾组织进行组织病理学和免疫组织化学分析。

结果

组织病理学和免疫组织化学染色结果表明，脑创伤可能导致肾损伤，而Tasi具有改善与TBI相关肾损伤的潜力。已发现Trau - Tasi - 10组在治疗上比Trau - Tasi - 1组更有效。

结论

通过组织病理学和免疫组织化学染色结果，我们观察到Tasi在TBI大鼠中具有改善肾损伤的活性。

补充信息

网络版包含可在10.1007/s00068 - 025 - 02915 - 6获取的补充材料。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ac9/12205017/2493e3259a14/68_2025_2915_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ac9/12205017/f04fab01fe47/68_2025_2915_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ac9/12205017/35e683928d0e/68_2025_2915_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ac9/12205017/a4c6fbc3f837/68_2025_2915_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ac9/12205017/751afd9f9997/68_2025_2915_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ac9/12205017/4d280c33777c/68_2025_2915_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ac9/12205017/2493e3259a14/68_2025_2915_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ac9/12205017/f04fab01fe47/68_2025_2915_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ac9/12205017/35e683928d0e/68_2025_2915_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ac9/12205017/a4c6fbc3f837/68_2025_2915_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ac9/12205017/751afd9f9997/68_2025_2915_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ac9/12205017/4d280c33777c/68_2025_2915_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ac9/12205017/2493e3259a14/68_2025_2915_Fig6_HTML.jpg

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