Safarzadeh Hanieh, Aliramezani Amir, Rahimi Arian, Yousefi Bahareh, Heidarzadeh Siamak
Department of Microbiology and Virology, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran.
Department of Microbiology, Faculty of Biochemistry, Biophysics, and Biotechnology, Jagiellonian University, Kraków, Poland.
Future Microbiol. 2025 Jul;20(10):695-706. doi: 10.1080/17460913.2025.2520699. Epub 2025 Jun 27.
In recent years, the incidence of metabolic disorders has exponentially increased worldwide mainly due to the misfunctioning of chemical reactions. Gestational diabetes mellitus (GDM) occurred during pregnancy when placenta prevent absorption of sufficient insulin in mother's body. Although this disorder usually disappears after delivery, it could raise the probability of developing complications in the future. GDM is associated with adverse effects on women and their children, such as obesity, cardiovascular disease, and type 2 diabetes. On the other hand, administration of probiotics as a live microorganism with the wide array of health values could contribute to restore and stabilize gut microbiota and subsequently regulate essential internal functions such as development of immunity. In this review, we focus primarily on some causes and effects of GDM in pregnant women and then , the most abundant butyrate-producing bacterium in gut, which have been using as a prominent biomarker in health and disease and also potential anti-inflammatory treatment owing to the production of active molecules.
近年来,由于化学反应功能失调,代谢紊乱在全球范围内的发病率呈指数级增长。妊娠期糖尿病(GDM)发生在孕期,此时胎盘会阻碍母体充分吸收胰岛素。尽管这种病症通常在分娩后消失,但它可能会增加未来发生并发症的几率。GDM会对女性及其子女产生不良影响,如肥胖、心血管疾病和2型糖尿病。另一方面,益生菌作为一种具有广泛健康价值的活微生物,其施用有助于恢复和稳定肠道微生物群,进而调节诸如免疫发育等重要的内部功能。在本综述中,我们主要关注孕妇GDM的一些成因和影响,然后关注肠道中最丰富的产丁酸盐细菌,它已被用作健康和疾病的重要生物标志物,并且由于能产生活性分子而具有潜在的抗炎治疗作用。