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解析胰腺癌微环境：微小RNA的多方面调控

Decoding the pancreatic cancer microenvironment: The multifaceted regulation of microRNAs.

作者信息

Ji Jie, Jin Dandan, Zhao Junpeng, Xie Xudong, Jiao Yujie, He Xuyang, Huang Yuxuan, Zhou Lirong, Xiao Mingbing, Cao Xiaolei

机构信息

Department of Gastroenterology, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong, Jiangsu, China.

Department of Gastroenterology, Affiliated Changshu Hospital of Nantong University, Changshu, Jiangsu, China.

出版信息

Clin Transl Med. 2025 Jul;15(7):e70354. doi: 10.1002/ctm2.70354.

DOI:10.1002/ctm2.70354
PMID:40579785
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12205012/
Abstract

Pancreatic cancer (PC) is an extremely deadly type of cancer, and the 5-year survival rate remains less than 10%. The tumour microenvironment (TME) affects the occurrence, progression and treatment outcomes of PC. MicroRNAs (miRNAs) are essential to regulate PC TME. This review delves into the different roles of miRNAs in the PC TME, including exosome communication, angiogenesis, interactions with cancer-associated fibroblasts, the immunological and neuronal microenvironments and metabolic reprogramming. However, research on the complex regulatory networks and synergistic effects of miRNAs in the TME is still insufficient, and their clinical translation and application face challenges. This review summarised the activities of miRNAs in the PC TME, guiding future research and therapeutic strategies involving miRNAs in PC. Future studies should integrate advanced technologies to decode the spatiotemporal dynamics of miRNA regulation within the TME and develop optimised nanodelivery systems for stable and targeted miRNA delivery, advancing clinical applications in PC treatment.

摘要

胰腺癌（PC）是一种极其致命的癌症类型，其5年生存率仍低于10%。肿瘤微环境（TME）影响着胰腺癌的发生、发展和治疗结果。微小RNA（miRNA）对调节胰腺癌TME至关重要。本综述深入探讨了miRNA在胰腺癌TME中的不同作用，包括外泌体通讯、血管生成、与癌症相关成纤维细胞的相互作用、免疫和神经微环境以及代谢重编程。然而，关于miRNA在TME中的复杂调控网络和协同作用的研究仍然不足，其临床转化和应用面临挑战。本综述总结了miRNA在胰腺癌TME中的活性，为未来涉及miRNA的胰腺癌研究和治疗策略提供指导。未来的研究应整合先进技术，以解码TME内miRNA调控的时空动态，并开发优化的纳米递送系统，以实现稳定且靶向的miRNA递送，推动其在胰腺癌治疗中的临床应用。

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本文引用的文献

[1]
Cancer associated fibroblasts in cancer development and therapy.

J Hematol Oncol. 2025-3-28

[2]
Regulatory T cells converted from Th1 cells in tumors suppress cancer immunity via CD39.

J Exp Med. 2025-4-7

[3]
Frontiers in pancreatic cancer on biomarkers, microenvironment, and immunotherapy.

Cancer Lett. 2025-2-1

[4]
Pancreatic cancer-derived exosomal miR-510 promotes macrophage M2 polarization and facilitates cancer cell aggressive phenotypes.

Hum Cell. 2024-11-12

[5]
Known and unknown: Exosome secretion in tumor microenvironment needs more exploration.

Genes Dis. 2023-11-23

[6]
Cancer-associated fibroblast-derived exosome Leptin promotes malignant biological lineage in pancreatic ductal adenocarcinoma by regulating ABL2 via miR-224-3p.

Mol Biol Rep. 2024-9-19

[7]
Noncoding Ribonucleic Acids (RNAs) May Improve Response to Immunotherapy in Pancreatic Cancer.

ACS Pharmacol Transl Sci. 2024-8-7

[8]
miR-6855-5p Enhances Radioresistance and Promotes Migration of Pancreatic Cancer by Inducing Epithelial-Mesenchymal Transition via Suppressing FOXA1: Potential of Plasma Exosomal miR-6855-5p as an Indicator of Radiosensitivity in Patients with Pancreatic Cancer.

Ann Surg Oncol. 2025-2

[9]
Unveiling the resistance to therapies in pancreatic ductal adenocarcinoma.

Drug Resist Updat. 2024-11

[10]
Circular RNA LIPH promotes pancreatic cancer glycolysis and progression through sponge miR-769-3p and interaction with GOLM1.

Clin Transl Med. 2024-8

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