Kurihara Fumiya, Hempstock Wendy, Ishizuka Noriko, Hayashi Hisayoshi
Laboratory of Physiology, School of Food and Nutritional Sciences, University of Shizuoka, Yada 52-1, Suruga-ku, Shizuoka 422-8526 Japan.
Laboratory of Physiology, School of Food and Nutritional Sciences, University of Shizuoka, Yada 52-1, Suruga-ku, Shizuoka 422-8526 Japan; Junior College, University of Shizuoka, Oshika 2-2-1, Suruga-ku, Shizuoka, 422-8021, Japan.
J Physiol Sci. 2025 Jul;75(2):100030. doi: 10.1016/j.jphyss.2025.100030. Epub 2025 Jun 20.
Aging is understood to be a time-dependent decline in various physiological functions. Motor and sensory functions deteriorate relatively early after maturity, while nutrient absorption and barrier functions in the digestive tract are reported to decline later, but the specific sites and mechanisms remain unclear. Senescence-Accelerated Mouse Prone 1 (SAMP1) mice (9 months) and C57BL/6 mice (over 19 months) were used to examine age-related changes in intestinal function of different regions using Ussing chambers. In SAMP1 mice, nutrient absorption and tight junction cationic permeability were reduced, while barrier function was enhanced in the middle and distal small intestine. Similar functional declines were observed in the distal small intestine of aged C57BL/6 mice. These findings suggest that the effect of aging is first observed in the distal small intestine, and that cation selectivity of the epithelial intercellular tight junction could serve as a new indicator for aging and functional evaluation index.
衰老被认为是各种生理功能随时间的衰退。运动和感觉功能在成熟后相对较早地恶化，而据报道消化道的营养吸收和屏障功能在后期才会下降，但具体部位和机制仍不清楚。使用衰老加速小鼠易感1型（SAMP1）小鼠（9个月）和C57BL/6小鼠（超过19个月），通过尤斯灌流小室来研究不同区域肠道功能的年龄相关变化。在SAMP1小鼠中，营养吸收和紧密连接阳离子通透性降低，而在小肠中部和远端屏障功能增强。在老年C57BL/6小鼠的远端小肠中也观察到了类似的功能衰退。这些发现表明，衰老的影响首先在远端小肠中观察到，并且上皮细胞间紧密连接的阳离子选择性可以作为衰老的新指标和功能评估指标。
