Hendra Kalen, Cui Xin, Main Elliot, Lee Henry C, Lin Gomez Scarlett, Shariff-Marco Salma, Jensen Erik A, Profit Jochen
Division of Pediatric Pulmonary Medicine, Department of Pediatrics, Stanford University School of Medicine, Palo Alto, CA.
Division of Neonatal & Developmental Medicine, Department of Pediatrics, Stanford University School of Medicine, Palo Alto, CA; California Perinatal Quality Care Collaborative, Palo Alto, CA.
J Pediatr. 2025 Jun 26;286:114706. doi: 10.1016/j.jpeds.2025.114706.
To characterize incidences of bronchopulmonary dysplasia (BPD) and oxygen use at discharge in infants with very low birth weight by Asian American, Native Hawaiian, and Pacific Islander (AANHPI) ethnicity.
We studied infants with very low birth weight born in California from 2012 to 2019. Infants of AANHPI mothers were studied in aggregate, were disaggregated by maternal ethnicity, and were compared with infants of Black, Hispanic, and non-Hispanic White (NHW) mothers. BPD was defined as the use of supplemental oxygen at 36 weeks postmenstrual age. Multivariable generalized estimating equation Poisson regression models adjusting for infant, maternal, and hospital-level factors compared outcomes across racial and ethnic groups using NHW as the reference.
We studied 29 467 infants whose mothers self-identified as AANHPI (n = 5002), Black (n = 3711), Hispanic (n = 14 168), and NHW (n = 6586). In infants of AANHPI mothers, incidences of BPD and oxygen use at discharge were 24.9% (disaggregated range: 16.9%-30.5%) and 9.2% (disaggregated range: 5.8%-14.5%), respectively. Compared with infants of NHW mothers, infants of Asian Indian mothers had a significantly lower risk of BPD (adjusted relative risk [aRR] 0.71) and oxygen use at discharge (aRR 0.66), whereas infants of Chinese and Korean mothers had a significantly higher risk of BPD (aRR 1.28 and aRR 1.45, respectively) and oxygen use at discharge (aRR 1.46 and aRR 1.77, respectively).
AANHPI data disaggregation demonstrated variability in incidences of BPD and oxygen use at discharge, and variability in risk compared with infants of NHW mothers. Our study highlights disparities across this diverse group that is typically studied in aggregate.
按亚裔美国人、夏威夷原住民和太平洋岛民（AANHPI）种族特征描述极低出生体重婴儿支气管肺发育不良（BPD）的发生率及出院时的吸氧情况。
我们研究了2012年至2019年在加利福尼亚州出生的极低出生体重婴儿。对AANHPI母亲的婴儿进行总体研究，按母亲种族进行细分，并与黑人、西班牙裔和非西班牙裔白人（NHW）母亲的婴儿进行比较。BPD定义为孕龄36周时使用补充氧气。多变量广义估计方程泊松回归模型对婴儿、母亲和医院层面的因素进行了调整，以NHW为参照比较了不同种族和族裔群体的结局。
我们研究了29467名母亲自我认定为AANHPI（n = 5002）、黑人（n = 3711）、西班牙裔（n = 14168）和NHW（n = 6586）的婴儿。在AANHPI母亲的婴儿中，BPD的发生率和出院时吸氧的发生率分别为24.9%（细分范围：16.9%-30.5%）和9.2%（细分范围：5.8%-14.5%）。与NHW母亲的婴儿相比，印度裔母亲的婴儿患BPD的风险（调整后相对风险[aRR] 0.71）和出院时吸氧的风险（aRR 0.66）显著更低，而中国和韩国母亲的婴儿患BPD的风险（分别为aRR 1.28和aRR 1.45）和出院时吸氧的风险（分别为aRR 1.46和aRR 1.77）显著更高。
AANHPI数据细分显示了BPD发生率和出院时吸氧情况的差异，以及与NHW母亲的婴儿相比风险的差异。我们的研究突出了这一通常作为一个整体进行研究的多样化群体之间的差异。
