中性粒细胞百分比与白蛋白比值作为预测乙肝相关慢加急性肝衰竭患者死亡率的新指标
Neutrophil percentage-to-albumin ratio as a novel predictor of mortality in HBV-Related acute-on-chronic liver failure.
作者信息
Waili Yulituzi, Xiang Yang, Mao WeiLin
机构信息
Department of Clinical Laboratory, The Sixth Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, China.
Department of Endocrinology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
出版信息
Biomark Med. 2025 Jul;19(14):623-628. doi: 10.1080/17520363.2025.2525072. Epub 2025 Jun 29.
BACKGROUND
HBV-related acute-on-chronic liver failure (HBV-ACLF) has a high short-term mortality rate, making early prognosis vital. This study investigated the predictive value of the neutrophil percentage-to-albumin ratio (NPAR) in HBV-ACLF.
METHODS
This retrospective study analyzed consecutive patients hospitalized with HBV-ACLF to identify risk factors for 90-day mortality. Disease severity was assessed using the Model for End-Stage Liver Disease (MELD) score, and multivariate regression analysis was performed to identify independent risk factors for mortality.
RESULTS
A total of 189 patients with HBV-ACLF were included in the analysis. The 90-day mortality rate was 45.5%. Higher NPAR levels were markedly associated with an increased mortality risk and were identified as an independent predictor comparable to the MELD score. The combination of NPAR and MELD score provided better prognostic accuracy than use of either marker alone.
CONCLUSIONS
NPAR is a valuable predictor of 90-day mortality in HBV-ACLF patients, and its combination with the MELD score improves prognostic accuracy.
背景
乙型肝炎病毒相关慢加急性肝衰竭（HBV-ACLF）具有较高的短期死亡率，因此早期预后至关重要。本研究调查了中性粒细胞百分比与白蛋白比值（NPAR）在HBV-ACLF中的预测价值。
方法
这项回顾性研究分析了连续住院的HBV-ACLF患者，以确定90天死亡率的危险因素。使用终末期肝病模型（MELD）评分评估疾病严重程度，并进行多因素回归分析以确定死亡的独立危险因素。
结果
共有189例HBV-ACLF患者纳入分析。90天死亡率为45.5%。较高的NPAR水平与死亡风险增加显著相关，并被确定为与MELD评分相当的独立预测因子。NPAR与MELD评分相结合比单独使用任何一种指标具有更好的预后准确性。
结论
NPAR是HBV-ACLF患者90天死亡率的有价值预测因子，其与MELD评分相结合可提高预后准确性。
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