场强、性别和年龄对肾脏伪连续动脉自旋标记及T图谱的影响

Influence of Field Strength, Sex, and Age on Pseudo-Continuous Arterial Spin Labeling and T Mapping in the Kidney.

作者信息

Garcia-Ruiz Leyre, Echeverria-Chasco Rebeca, Aramendía-Vidaurreta Verónica, Solis-Barquero Sergio M, Garcia-Fernandez Nuria, Mora-Gutiérrez José María, Vidorreta Marta, Bastarrika Gorka, Fernández-Seara Maria A

机构信息

Radiology Department, Clínica Universidad de Navarra, Pamplona, Spain.

Instituto de Investigación Sanitaria de Navarra (IDISNA), Pamplona, Spain.

出版信息

J Magn Reson Imaging. 2025 Jun 30. doi: 10.1002/jmri.70009.

DOI:10.1002/jmri.70009

PMID:40583469

Abstract

BACKGROUND

Pseudo-continuous arterial spin labeling (PCASL) and T mapping have been used for renal imaging at 1.5 T and 3 T. However, direct comparisons between field strengths, age, and sex are lacking.

PURPOSE

To assess the effects of field strength, age, and sex on renal perfusion and T values and measure reproducibility.

STUDY TYPE

Prospective.

POPULATION

Sixteen healthy volunteers (eight females, age 41.8 ± 13.3 years) underwent same-day scans at 1.5 T and 3 T, repeated 1 week later.

FIELD STRENGTH/SEQUENCE: 1.5 T/3 T multi-delay PCASL with spin-echo EPI readout, inversion-recovery T mapping, B and B mapping.

ASSESSMENT

Multi-delay PCASL was employed to calculate renal blood flow (RBF) and arterial transit time (ATT) maps; single-delay PCASL (PLD = 1.3 s) assessed RBF and technical parameters. Cortical and medullary RBF, ATT, and T were compared between field strengths, age, and sex groups. Reproducibility and inter-observer agreement were evaluated.

STATISTICAL TESTS

Shapiro-Wilk test, analysis of variance, Levene test, Box M-test, Pearson's correlation, within-subject coefficient of variation (wsCV), and intraclass correlation coefficient (ICC). P-value < 0.05 was significant.

RESULTS

3 T yielded significantly higher cortical T (1356.02 ± 3.72 vs. 1023.29 ± 39.30 ms), and lower RBF (310.63 ± 52.72 vs. 347.65 ± 54.08 [mL/min/100 g]) than 1.5 T. Eight older (≥ 40 years) participants had significantly lower cortical RBF (1.5 T: 312.23 ± 37.59 vs. 383.06 ± 43.91 [mL/min/100 g]). Females showed significantly shorter ATT (1.5 T: 0.75 ± 0.11 s vs. 0.96 ± 0.22 s) and longer medullary T (1.5 T: 1388.12 ± 33.68 ms vs. 1308.97 ± 28.52 ms). T showed excellent reproducibility and inter-observer agreement (wsCV: < 2%, ICC: > 0.8). Cortical RBF was reproducible (wsCV: ~10%, ICC: > 0.7) with strong inter-observer agreement (wsCV: < 2.5%, ICC > 0.95). Medullary RBF had good inter-observer agreement (wsCV: < 4.7%, ICC: > 0.75) but poor reproducibility (wsCV: 15.78%-19.38%).

DATA CONCLUSION

Cortical perfusion parameters and T were reproducible. However, age, sex, and field strength affect the values, requiring consideration in renal imaging.

EVIDENCE LEVEL

Level 2.

TECHNICAL EFFICACY

Stage 1.

摘要

背景

伪连续动脉自旋标记（PCASL）和T值映射已用于1.5T和3T场强下的肾脏成像。然而，目前尚缺乏场强、年龄和性别之间的直接比较。

目的

评估场强、年龄和性别对肾脏灌注和T值的影响，并测量其可重复性。

研究类型

前瞻性研究。

研究对象

16名健康志愿者（8名女性，年龄41.8±13.3岁）在同一天接受1.5T和3T场强扫描，并在1周后重复扫描。

场强/序列：1.5T/3T多延迟PCASL，采用自旋回波EPI读出、反转恢复T值映射、B和B值映射。

评估

采用多延迟PCASL计算肾血流量（RBF）和动脉通过时间（ATT）图；单延迟PCASL（PLD = 1.3s）评估RBF和技术参数。比较不同场强、年龄和性别组之间的皮质和髓质RBF、ATT和T值。评估可重复性和观察者间一致性。

统计检验

Shapiro-Wilk检验、方差分析、Levene检验、Box M检验、Pearson相关性分析、受试者内变异系数（wsCV）和组内相关系数（ICC）。P值<0.05具有统计学意义。

结果

与1.5T相比，3T场强下皮质T值显著更高（1356.02±3.72 vs. 1023.29±39.30ms），RBF更低（310.63±52.72 vs. 347.65±54.08[mL/min/100g]）。8名年龄较大（≥40岁）的参与者皮质RBF显著更低（1.5T：312.23±37.59 vs. 383.06±43.91[mL/min/100g]）。女性的ATT显著更短（1.5T：0.75±0.11s vs. 0.96±0.22s），髓质T值更长（1.5T：1388.12±33.68ms vs. 1308.97±28.52ms）。T值具有出色的可重复性和观察者间一致性（wsCV：<2%，ICC：>0.8）。皮质RBF具有可重复性（wsCV：~10%，ICC：>0.7），观察者间一致性强（wsCV：<2.5%，ICC>0.95）。髓质RBF具有良好的观察者间一致性（wsCV：<4.7%，ICC：>0.75），但可重复性较差（wsCV：15.78%-19.38%）。