Chen Lingling, Wang Jinxia, Gao Yanping, Xiu Wenbo, Wang Zuo, Zhang Gao, Li An, Chen Yang, Deng Bolin, Lu Fang, He Chong, Hu Lijuan
Department of Immunology, West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, Chengdu, China.
Clinical Immunology Translational Medicine Key Laboratory of Sichuan Province, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.
Biomark Med. 2025 Jul;19(14):597-604. doi: 10.1080/17520363.2025.2523236. Epub 2025 Jun 30.
To explore the relationship between plasma myeloperoxidase (MPO) and glaucoma, assessing the clinical utility of MPO in glaucoma.
A cross-sectional study involved 127 glaucoma patients and 106 healthy controls. Plasma MPO markers were quantified using enzyme-linked immunosorbent assay (ELISA), comparing levels between glaucoma patients and healthy controls, and analyzing plasma MPO across different glaucoma severity grades.
In this study, we observed elevated plasma MPO levels in glaucoma patients ( < 0.001). After correcting for confounders such as age, sex, hypertension, and diabetes, plasma MPO remained independently associated with glaucoma (OR = 1.05, 95% CI: 1.04-1.07, < 0.001). Plasma MPO may reflect the severity of glaucoma, with significant differences in plasma MPO observed between early and severe stages, but not in the moderate stages. In addition, elevated plasma MPO was associated with higher cup-to-disc ratios. ROC curve analysis demonstrated the validity of glaucoma markers in identifying early glaucoma from severe glaucoma (early versus severe: AUC = 0.633).
Elevated plasma MPO levels are independently associated with glaucoma risk, suggesting it might provide insight into disease pathogenesis.
探讨血浆髓过氧化物酶（MPO）与青光眼之间的关系，评估MPO在青光眼方面的临床应用价值。
一项横断面研究纳入了127例青光眼患者和106例健康对照者。采用酶联免疫吸附测定（ELISA）对血浆MPO标志物进行定量，比较青光眼患者与健康对照者之间的水平，并分析不同青光眼严重程度分级的血浆MPO情况。
在本研究中，我们观察到青光眼患者血浆MPO水平升高（<0.001）。在校正年龄、性别、高血压和糖尿病等混杂因素后，血浆MPO仍与青光眼独立相关（OR=1.05，95%CI：1.04-1.07，<0.001）。血浆MPO可能反映青光眼的严重程度，早期和重度阶段的血浆MPO存在显著差异，但中度阶段无差异。此外，血浆MPO升高与更高的杯盘比相关。ROC曲线分析证明了青光眼标志物在区分早期青光眼与重度青光眼方面的有效性（早期与重度：AUC=0.633）。
血浆MPO水平升高与青光眼风险独立相关，提示其可能为疾病发病机制提供线索。
