There has been an increase in interest in using in-office cosmetic treatments to promote collagen in the skin and deeper tissues. The current study assesses the safety and efficacy of the combination of a 675 nm laser wavelength and the injection of soft tissue fillers based on hyaluronic acid (HA) during facial rejuvenation treatments. A total of 16 patients treated for facial skin rejuvenation and reduction of facial laxity were divided into two groups: Group 1 underwent three sessions of a 675 nm laser system combined with three sessions of HA filler and Group 2 received three sessions of the 675 nm laser system alone. One treatment every 30 days for 3 months was performed. Images were acquired at baseline (T), after the second session (T), and 1 month after the last treatment (T). A dermal analysis system was employed for skin analysis. The 10-point visual analog scale and the 5-point Global Aesthetic Improvement Scale (GAIS) were used. In both groups, but more promisingly in Group 1, the skin showed an improvement in its elasticity reported with an increase in Young's modulus, a decrease in retraction time, and an increase in viscoelasticity. Qualitative analysis of high-frequency dermal ultrasound images showed significant increases in new collagen density and dermal thickness. These results were confirmed with the GAIS. No side effects were recorded. The findings indicate that the combination of 675 nm laser and HA filler was well-tolerated and safe and has shown promising results for treating skin aging.