Liu Yujiao, Zhang Zixuan, Su Zhenhan, Deng Yuhong, Lin Chuhui, Tian Wei
School of Life Science and Biopharmaceuticals, Shenyang Pharmaceutical University, Shenyang, Liaoning, People's Republic of China.
Department of Clinical Nutrition, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, People's Republic of China.
Diabetes Metab Syndr Obes. 2025 Jun 23;18:1999-2006. doi: 10.2147/DMSO.S509561. eCollection 2025.
To investigate the therapeutic effect of the culture broth of on diabetic foot ulcer rats.
The diabetic foot ulcer model was established by combined treatment of streptozotocin (STZ) and hindfoot injury in rats. The rats were divided into groups: control, model, low-dose, and high-dose of culture broth. Blood sugar and wound area were measured. ELISA determined levels of TNF-α, IL-6, and VEGF. H&E staining observed damaged skin tissues.
Compared to the model group, the culture broth of could lower blood glucose levels and decrease the wound area. It could notably decrease the concentration of TNF-α and IL-6, inhibit the expression of inflammatory factors in skin tissues, enhances the expression of VEGF and accelerate wound healing.
The culture broth can effectively facilitate wound healing of foot injury in diabetic rats and has a certain therapeutic effect on diabetic foot. The study explores an alternative therapy from natural sources to address a gap in diabetic foot ulcer management. It provides a foundation for further research on Laetiporus sulphureus as a novel treatment.
探讨[具体名称未给出]培养液对糖尿病足溃疡大鼠的治疗作用。
通过链脲佐菌素（STZ）和大鼠后足损伤联合处理建立糖尿病足溃疡模型。将大鼠分为对照组、模型组、低剂量[具体名称未给出]培养液组和高剂量[具体名称未给出]培养液组。测量血糖和伤口面积。采用酶联免疫吸附测定法（ELISA）测定肿瘤坏死因子-α（TNF-α）、白细胞介素-6（IL-6）和血管内皮生长因子（VEGF）水平。苏木精-伊红（H&E）染色观察受损皮肤组织。
与模型组相比，[具体名称未给出]培养液可降低血糖水平，减小伤口面积。它能显著降低TNF-α和IL-6的浓度，抑制皮肤组织中炎症因子的表达，增强VEGF的表达并加速伤口愈合。
[具体名称未给出]培养液可有效促进糖尿病大鼠足部损伤的伤口愈合，对糖尿病足有一定治疗作用。该研究探索了一种来自天然来源的替代疗法，以填补糖尿病足溃疡管理方面的空白。它为进一步研究硫黄多孔菌作为一种新的治疗方法提供了基础。
