Bai Jiang, Zhang Lijuan, He Letian, Zhou Yun
Department of Nephrology, The First Hospital of Shanxi Medical University, Taiyuan, China.
The First Clinical Medical School, Shanxi Medical University, Taiyuan, China.
Front Nutr. 2025 Jun 13;12:1613640. doi: 10.3389/fnut.2025.1613640. eCollection 2025.
Metabolic dysfunction-associated steatotic liver disease (MASLD) and chronic kidney disease (CKD) have been demonstrated to be intricately linked in a multitude of research studies. The reclassification of MASLD has prompted a reevaluation of its epidemiological patterns and the associated risk of CKD. This is crucial as MASLD, focusing on cardiometabolic factors, might have a more pronounced association with CKD than NAFLD. Additionally, mitochondrial dysfunction has been implicated in the pathogenesis of both MASLD and CKD. Studies on metabolic dysfunction-associated steatohepatitis mouse models have revealed significant mitochondrial alterations, such as loss of cristae and impaired function in the kidneys, underscoring the critical importance of mitochondrial integrity in these pathologies. This review offers an extensive overview of the existing literature, covering the following key aspects: (a) presenting the latest epidemiological findings that elucidate the relationship between MASLD and CKD; (b) kidney pathological changes associated with MASLD; (c) mitochondrial alterations in MASLD and CKD, including oxidative stress, dynamics, and mitophagy; and (d) potential mitochondrial-targeted therapies.
代谢功能障碍相关脂肪性肝病（MASLD）和慢性肾脏病（CKD）在众多研究中已被证明存在复杂的联系。MASLD的重新分类促使人们重新评估其流行病学模式以及与CKD相关的风险。这至关重要，因为专注于心血管代谢因素的MASLD与CKD的关联可能比非酒精性脂肪性肝病（NAFLD）更为显著。此外，线粒体功能障碍与MASLD和CKD的发病机制均有关联。对代谢功能障碍相关脂肪性肝炎小鼠模型的研究揭示了显著的线粒体改变，如嵴的丧失和肾脏功能受损，强调了线粒体完整性在这些疾病中的关键重要性。本综述对现有文献进行了广泛概述，涵盖以下关键方面：（a）呈现阐明MASLD与CKD关系的最新流行病学发现；（b）与MASLD相关的肾脏病理变化；（c）MASLD和CKD中的线粒体改变，包括氧化应激、动力学和线粒体自噬；以及（d）潜在的线粒体靶向治疗。
