Liu Xiaoxia, Li Qiufu, Zhang Liyuan, He Ying, Tan Sitao, Chen Xiaoyu, Li Kefeng
Center for Artificial Intelligence Driven Drug Discovery, Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.
Department of Pharmacy, The People's Hospital of Guangxi Zhuang Autonomous Region, Guangxi Academy of Medical Sciences, Nanning, China.
Front Nutr. 2025 Jun 13;12:1594507. doi: 10.3389/fnut.2025.1594507. eCollection 2025.
The aim of this study was to summarize the effects of amino acids (AA) on renal function and nutritional indices in patients with renal insufficiency (RI) after treatment and to analyze the development trend in this field.
The bibliometric evaluation of scholarly contributions in this field was conducted using the Web of Science database, with data analyzed via Bibliometrix and VOSviewer software. The randomized controlled trials (RCTs) published before January 13, 2025, were systematically retrieved from Embase, PubMed, and the Cochrane Library and meta-analyses were performed using Review Manager 5.4 software.
Key areas of focus included oxidative stress, chronic renal failure, hemodialysis, inflammation, chronic kidney disease, risk, plasma, progression, L-arginine, disease, and renal failure. Nine RCTs involving 407 participants were included, AA administration demonstrated significant effects compared to placebo: Increased blood urea nitrogen (MD: 4.21, 95% CI: 1.08 to 7.35, = 0.008), elevated renal plasma flow (MD: 30.78, 95% CI: 15.36 to 46.21, < 0.0001), and reduced uric acid levels (MD: -0.47, 95% CI: -0.89 to -0.06, = 0.02).
These findings suggest that AA supplementation may partially improve renal function in RI patients. The progression and possible mechanisms of chronic kidney disease, as well as the search for new biomarkers, will be the trend of research and development in this field.
本研究旨在总结氨基酸（AA）对肾功能不全（RI）患者治疗后肾功能及营养指标的影响，并分析该领域的发展趋势。
使用Web of Science数据库对该领域的学术贡献进行文献计量学评估，通过Bibliometrix和VOSviewer软件分析数据。从Embase、PubMed和Cochrane图书馆系统检索2025年1月13日前发表的随机对照试验（RCT），并使用Review Manager 5.4软件进行荟萃分析。
重点关注领域包括氧化应激、慢性肾衰竭、血液透析、炎症、慢性肾脏病、风险、血浆、进展、L-精氨酸、疾病和肾衰竭。纳入9项涉及407名参与者的RCT，与安慰剂相比，AA给药显示出显著效果：血尿素氮升高（MD：4.21，95%CI：1.08至7.35，P = 0.008），肾血浆流量升高（MD：30.78，95%CI：15.36至46.21，P < 0.0001），尿酸水平降低（MD：-0.47，95%CI：-0.89至-0.06，P = 0.02）。
这些发现表明，补充AA可能部分改善RI患者的肾功能。慢性肾脏病的进展及可能机制，以及寻找新的生物标志物，将是该领域的研发趋势。
