人血白蛋白注射是治疗低蛋白血症的最佳选择吗？
Is human albumin injection the best choice to treat hypoalbuminemia?
机构信息
Department of Pharmacy, Hebei General Hospital, Shijiazhuang, China.
Department of Science and Education, Tangshan People's Hospital, Tangshan, China.
出版信息
PLoS One. 2024 Oct 21;19(10):e0311949. doi: 10.1371/journal.pone.0311949. eCollection 2024.
BACKGROUND
Currently, there is an irrational use of drugs in the treatment of hypoproteinemia. This study evaluates the value of 12 injections to provide a basis for drug selection for the treatment of hypoproteinemia.
METHODS
The content of the first restrictive amino acid, the comprehensive quality of the total essential amino acid, and the closeness to the whole egg protein or FAO/WHO model were evaluated to compare their value in the amino acid synthesis of human serum albumin. A comparison was made between the matching degree of HA and therapeutic amino acids with the human plasma amino acid profile. Furthermore, the value and safety of synthetic human serum albumin were compared.
RESULTS
The lowest synthetic value of human serum albumin was 18AA-V, and the highest was 18AA-II. The CS values of HA, 18AA-V, 18AA-II, 18AA-Ip, 18AA-IIp, and 19AA-Ip were 0.18, 0.58, 0.78, 0.55, 0.54, and 0.59, respectively. The similarity to egg protein was 0.81, 0.92, 0.94, 1.00, 1.18, and 1.18, respectively. The proximity values to FAO/WHO standards were 0.81, 0.85, 0.90, 1.36, 1.54, and 1.54, respectively. The changes in 3AA and the amino acid profile were matched when liver function was abnormal. When the renal function was abnormal, 9AA was matched. During trauma, 18AA-VII was matched. The amino acid profile of HA did not correspond.
CONCLUSION
Patients with normal liver and kidney function should choose compound balanced amino acid injection, while patients with abnormalities should choose 3AA. Patients with renal dysfunction should choose 9AA. Trauma patients should choose 18AA-VII.
背景
目前，在低蛋白血症的治疗中存在不合理用药的情况。本研究评估了 12 种注射液的价值，为低蛋白血症的药物选择提供依据。
方法
评估第一限制氨基酸含量、必需氨基酸总含量综合质量和接近全蛋蛋白或 FAO/WHO 模式的程度，比较其在人血清白蛋白合成中的价值。比较 HA 与治疗氨基酸与人体血浆氨基酸谱的匹配程度。此外，还比较了合成人血清白蛋白的价值和安全性。
结果
人血清白蛋白合成的最低值为 18AA-V，最高值为 18AA-II。HA、18AA-V、18AA-II、18AA-Ip、18AA-IIp 和 19AA-Ip 的 CS 值分别为 0.18、0.58、0.78、0.55、0.54 和 0.59。与鸡蛋蛋白的相似度分别为 0.81、0.92、0.94、1.00、1.18 和 1.18。与 FAO/WHO 标准的接近值分别为 0.81、0.85、0.90、1.36、1.54 和 1.54。当肝功能异常时，3AA 和氨基酸谱发生变化。当肾功能异常时，匹配 9AA。在创伤时，匹配 18AA-VII。HA 的氨基酸谱不对应。
结论
肝功能和肾功能正常的患者应选择复方平衡氨基酸注射液，异常的患者应选择 3AA。肾功能异常的患者应选择 9AA。创伤患者应选择 18AA-VII。
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