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急性和慢性皮肤移植物抗宿主病中的甲襞视频毛细血管镜检查

Nailfold Video Capillaroscopy in Acute and Chronic Skin Graft Versus Host Disease.

作者信息

Mumtaz Sehreen, Berianu Florentina, Bhullar Puneet, Phillipps Jordan, Iqbal Madiha, Hodge David, Cane Breanna, Sokumbi Olayemi

机构信息

Department of Rheumatology, Mayo Clinic, Jacksonville, FL.

Department of Dermatology, Mayo Clinic, Jacksonville, FL.

出版信息

Mayo Clin Proc Innov Qual Outcomes. 2025 Jun 13;9(4):100635. doi: 10.1016/j.mayocpiqo.2025.100635. eCollection 2025 Aug.

DOI:10.1016/j.mayocpiqo.2025.100635
PMID:40584561
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12205791/
Abstract

OBJECTIVE

To assess the utility of nailfold video capillaroscopy (NVC) in patients diagnosed with acute and chronic graft versus host disease (GVHD) of the skin.

PATIENTS AND METHODS

Patients diagnosed with acute and chronic skin GVHD (n=11) and those without the diagnosis of GVHD (controls) (n=21) underwent NVC to assess capillary density, morphology, and hemorrhage. Statistical comparisons were made using Fisher's exact test. The study was performed from March 1, 2024, to August 1, 2024.

RESULTS

Patients diagnosed with acute and chronic GVHD were observed to have considerably more microhemorrhages, ramifications, and disorganized capillaries when compared with patients without a diagnosis of acute or chronic GVHD.

CONCLUSION

This study reveals significant NVC abnormalities in patients with GVHD, suggesting distinct microvascular features that imply potential diagnostic value. The NVC may be a valuable tool for diagnosing and monitoring GVHD and warrants further investigation in larger cohorts.

摘要

目的

评估甲襞视频毛细血管镜检查（NVC）在诊断为皮肤急慢性移植物抗宿主病（GVHD）患者中的应用价值。

患者与方法

诊断为急慢性皮肤GVHD的患者（n = 11）和未诊断为GVHD的患者（对照组）（n = 21）接受NVC检查，以评估毛细血管密度、形态和出血情况。采用Fisher精确检验进行统计学比较。该研究于2024年3月1日至2024年8月1日进行。

结果

与未诊断为急慢性GVHD的患者相比，诊断为急慢性GVHD的患者观察到有更多的微出血、分支和毛细血管紊乱。

结论

本研究揭示了GVHD患者存在明显的NVC异常，提示有独特的微血管特征，具有潜在诊断价值。NVC可能是诊断和监测GVHD的有价值工具，值得在更大队列中进一步研究。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/148e/12205791/2cf2ccaa6ab2/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/148e/12205791/ffa96debfd93/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/148e/12205791/2cf2ccaa6ab2/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/148e/12205791/ffa96debfd93/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/148e/12205791/2cf2ccaa6ab2/gr2.jpg

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Nailfold capillaroscopy: from the early ages to the early diagnosis of systemic sclerosis.甲襞毛细血管镜检查：从早期到系统性硬化症的早期诊断
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Nailfold capillaroscopy changes with disease activity in patients with inflammatory myositis including overlap myositis, pure dermatomyositis, and pure polymyositis.在包括重叠性肌炎、单纯性皮肌炎和单纯性多发性肌炎在内的炎性肌病患者中，甲襞毛细血管镜检查结果随疾病活动度而变化。
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